{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:51:57Z","timestamp":1790175117357,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,7,13]],"date-time":"2011-07-13T00:00:00Z","timestamp":1310515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold> Although a decreased areal bone mineral density (BMD) has been reported in patients with haemophilia, data are lacking that would reflect the three\u2010dimensional structure of the bone and the muscle\u2010bone relationship. We aimed to assess volumetric BMD, bone geometry and muscle\u2010bone phenotype in boys with haemophilia, and to describe the association between clinical characteristics of haemophilia and bone quality and structure. A cross\u2010sectional study was conducted in 41 boys with haemophilia (mean age 12.4, range 6.6\u201319.8\u2003years) using peripheral quantitative CT (pQCT) at the nondominant forearm. Results were transformed into Z\u2010scores using previously published reference data. Significant differences were tested by one\u2010sample <jats:italic>t<\/jats:italic>\u2010test or sign test. Two\u2010sample <jats:italic>t<\/jats:italic>\u2010test and <jats:sc>anova<\/jats:sc> were used to compare results between subgroups of patients divided according to the severity of the disease, the fracture history and the number of joint and muscle bleedings. Boys with haemophilia had a decreased trabecular volumetric BMD (mean Z\u2010score \u22120.5, <jats:italic>P\u2003<\/jats:italic>&lt;\u20030.01), while their cortical volumetric BMD was increased (mean Z\u2010score 0.4, <jats:italic>P\u2003<\/jats:italic>&lt;\u20030.05). The volumetric bone mineral content and the bone geometry at the radial diaphysis were normal when adjusted for patients\u2019 shorter body height. Muscle area was decreased (mean Z\u2010score \u22121.0, <jats:italic>P\u2003<\/jats:italic>&lt;\u20030.001), irrespective of age. No association was observed of bone quality parameters and bone geometry with the disease severity, fracture history or number of bleedings. Bone strength measured at the diaphysis of the radius is not impaired in boys with haemophilia. The finding of the decreased trabecular bone density can be most likely attributed to their sarcopenia.<\/jats:p>","DOI":"10.1111\/j.1365-2516.2011.02616.x","type":"journal-article","created":{"date-parts":[[2011,7,14]],"date-time":"2011-07-14T02:07:50Z","timestamp":1310609270000},"page":"222-228","source":"Crossref","is-referenced-by-count":25,"title":["Boys with haemophilia have low trabecular bone mineral density and sarcopenia, but normal bone strength at the radius"],"prefix":"10.1111","volume":"18","author":[{"given":"O.","family":"SOUCEK","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"KOMRSKA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"HLAVKA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"CINEK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"ROCEK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"ZEMKOVA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"LEBL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"SUMNIK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,7,13]]},"reference":[{"key":"e_1_2_8_2_2","first-page":"181","article-title":"Association of severe haemophilia A with osteoporosis: a densitometric and biochemical study","volume":"87","author":"Gallacher SJ","year":"1994","journal-title":"Q J Med"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.114.2.e177"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20877"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06972.x"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01963.x"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-009-0759-x"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH09-09-0629"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-010-1333-z"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.172"},{"key":"e_1_2_8_11_2","first-page":"232","article-title":"From mechanostat theory to development of the \u201cfunctional muscle\u2010bone\u2010unit\u201d","volume":"5","author":"Schoenau E","year":"2005","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-001-0048-8"},{"key":"e_1_2_8_13_2","first-page":"126","article-title":"The 6th nationwide anthropological survey of children and adolescents in the Czech Republic in 2001","volume":"12","author":"Kobzova J","year":"2004","journal-title":"Cent Eur J Public Health"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001980170074"},{"key":"e_1_2_8_15_2","first-page":"119","article-title":"Peripheral quantitative computed tomography of the distal radius in young subjects \u2013 new reference data and interpretation of results","volume":"5","author":"Rauch F","year":"2005","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"e_1_2_8_16_2","first-page":"217","article-title":"Peripheral quantitative computed tomography of the proximal radius in young subjects \u2013 new reference data and interpretation of results","volume":"8","author":"Rauch F","year":"2008","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"e_1_2_8_17_2","first-page":"45","article-title":"The LMS method for constructing normalized growth standards","volume":"44","author":"Cole TJ","year":"1990","journal-title":"Eur J Clin Nutr"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2007.12.005"},{"key":"e_1_2_8_19_2","volume-title":"R: A Language and Environment for Statistical Computing","author":"Team RDC","year":"2011"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/10245330701383700"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2003.12.009"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2005.09.004"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2010.03955.x"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-003-1380-9"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2005.01116.x"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2009.02186.x"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1682\/JRRD.2008.12.0163"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2004.01.001"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2009.01.001"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01912.x"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.090824"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.218"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01460.x"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2516.2011.02616.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2516.2011.02616.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T05:10:27Z","timestamp":1698642627000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2516.2011.02616.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,13]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.1111\/j.1365-2516.2011.02616.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2516.2011.02616.x","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,13]]}}}