{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:35:30Z","timestamp":1789727730662,"version":"4.0.1"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,4,16]],"date-time":"2012-04-16T00:00:00Z","timestamp":1334534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold> Radiosynoviorthesis (RS) is an intra\u2010articular injection of a radioactive colloid for the treatment of synovitis administered most often to patients with rheumatoid arthritis or haemophilia. Although highly cost\u2010effective in comparison with surgical or arthroscopic synovectomy, the risk of cancer associated with this treatment is not well known. We evaluated the incidence of cancer in a group of patients treated with RS. A cohort of 2412 adult patients with a variety of underlying conditions (mainly rheumatoid arthritis) and treated with at least one RS between January 1976 and December 2001, was recruited from two centres in Montr\u00e9al. Cancer incidence and mortality data for cohort members over that time period were obtained from regulatory agencies using linkage. Background rates for all and specific types of cancer were obtained for the provincial (Qu\u00e9bec) and national (Canada) population according to age, gender and calendar period categories. Category\u2010specific rates in the cohort were compared with rates in similar categories from the general population generating standardized incidence ratios (SIR). The effects of specific isotope doses and of number of RS treatments were analysed using a Cox\u2010regression model. No increase in the risk of cancer was observed (SIR 0.96; 95% confidence interval 0.82\u20131.12). There was no dose\u2013response relationship with the amount of radioisotope administered or number of RS treatments. The study provides some indication for the safety of the procedure but homogenous diagnostic groups of younger patients (such as haemophilic patients) receiving RS will need more evaluation.<\/jats:p>","DOI":"10.1111\/j.1365-2516.2012.02802.x","type":"journal-article","created":{"date-parts":[[2012,4,16]],"date-time":"2012-04-16T08:37:26Z","timestamp":1334565446000},"page":"805-809","source":"Crossref","is-referenced-by-count":53,"title":["A retrospective cohort study of cancer incidence among patients treated with radiosynoviorthesis"],"prefix":"10.1111","volume":"18","author":[{"given":"C.","family":"INFANTE\u2010RIVARD","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.\u2010E.","family":"RIVARD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"DEROME","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"CUSSON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"WINIKOFF","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"CHARTRAND","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010P.","family":"GUAY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,4,16]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.22.6.435"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.32.Suppl.3"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apradiso.2007.09.003"},{"key":"e_1_2_7_5_2","first-page":"212","volume-title":"Radioactive gold in the treatment of chronic synovial effusion in haemophilia","author":"Ahlberg A","year":"1971"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2001.00109.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1613015"},{"key":"e_1_2_7_8_2","first-page":"753","article-title":"Synoviorthesis with colloidal 32P chromic phosphate for hemophilic arthropathy: clinical follow\u2010up","volume":"66","author":"Rivard GE","year":"1985","journal-title":"Arch Phys Med Rehabil"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01447.x"},{"key":"e_1_2_7_10_2","first-page":"165","article-title":"The efficacy and safety of radiosynovectomy","volume":"9","author":"Lee P","year":"1982","journal-title":"J Rheumatol"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2001.00110.x"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01406.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/cbr.2006.328"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.3.251"},{"key":"e_1_2_7_15_2","volume-title":"EpiData Data Entry, Data Management and basic Statistical Analysis System","author":"Lauritsen JM","year":"2000"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1557(199709\/10)6:5<331::AID-PDS297>3.0.CO;2-9"},{"key":"e_1_2_7_17_2","unstructured":"MASAC Recommendation # 176. MASAC Recommendations Regarding Radionuclide Synovectomy. October 15 2006.http:\/\/www.hemophilia.org."},{"key":"e_1_2_7_18_2","article-title":"Chronic hemophilic synovitis: the role of radiosynovectomy","author":"Silva M","journal-title":"Treatment of hemophilia"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2516.2012.02802.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2516.2012.02802.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T22:15:20Z","timestamp":1695507320000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2516.2012.02802.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,16]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.1111\/j.1365-2516.2012.02802.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2516.2012.02802.x","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,16]]}}}