{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T22:29:24Z","timestamp":1764714564711},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,5,8]],"date-time":"2012-05-08T00:00:00Z","timestamp":1336435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold> Sport is increasingly recommended for haemophilic patients due to physical and psychological benefits. \u2018WATERCISE\u2019 is a specific aqua\u2010training programme for haemophiliacs in which endurance, strength, coordination and mobility are trained. In the WAT\u2010QoL study benefits and risks of regular WATERCISE training sessions were investigated in terms of health\u2010related quality of life (HRQoL), physical functioning (PF), orthopaedic joint status (OJS), bleeding frequency and factor consumption. Patients in the WATERCISE group attended an aqua\u2010training programme once a week for 1\u2003h over 12\u2003months, patients in the control group did not. Patients were matched for clinical and demographic data. Information on clinical data, orthopaedic status, PF (HEP\u2010Test\u2010Q) and HRQoL were collected in both groups at baseline and at follow\u2010up (6 and 12\u2003months). Twenty\u2010eight adult severely affected haemophilic patients (WATERCISE group: 10 haemophilia A (HA), 3 haemophilia B (HB) patients; control group: 12 HA and 3 HB patients) were enrolled (aged 40.68\u2003\u00b1\u200312.7\u2003years). Baseline data (body mass indices, OJS, sportive activities, HRQoL and PF) were well distributed between groups. After 12\u2003months the WATERCISE group reported a significantly better PF (<jats:italic>M<\/jats:italic><jats:sub>W<\/jats:sub>\u2003=\u200365.22, SD\u2003=\u200311.3; <jats:italic>M<\/jats:italic><jats:sub>C<\/jats:sub>\u2003=\u200352.5, SD\u2003=\u200315.0), especially for endurance (<jats:italic>P\u2003<\/jats:italic>&lt;\u20030.004). Although always differently reported by the patients within the WATERCISE group, HRQoL did not prove to be significantly different between groups. WATERCISE seems to have a positive effect on the PF of patients suffering from haemophilia. These study findings need to be further investigated in a larger study group.<\/jats:p>","DOI":"10.1111\/j.1365-2516.2012.02819.x","type":"journal-article","created":{"date-parts":[[2012,5,8]],"date-time":"2012-05-08T10:51:38Z","timestamp":1336474298000},"page":"714-721","source":"Crossref","is-referenced-by-count":22,"title":["The impact of a specific aqua\u2010training for adult haemophilic patients \u2013 results of the WATERCISE study (WAT\u2010QoL)"],"prefix":"10.1111","volume":"18","author":[{"given":"S.","family":"Von MACKENSEN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"EIFRIG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Z\u00c4CH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"KALNINS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"WIELOCH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"ZELLER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,5,8]]},"reference":[{"key":"e_1_2_8_2_2","unstructured":"World Federation of Hemophilia.Guidelines for the Management of Hemophilia 2005."},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1615621"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01882.x"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04214.x"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11420-009-9140-9"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.1995.tb00103.x"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2009.08.001"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.9.s1.17.x"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1999.01463.x"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.1999.0050s1016.x"},{"key":"e_1_2_8_12_2","first-page":"97","article-title":"Physical activity and the hemophiliac: yes or no?","volume":"29","author":"Weigel N","year":"1975","journal-title":"Am Correct Ther J"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2000.00422.x"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199607000-00006"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2004.01000.x"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01505.x"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2003.00679.x"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2002.00575.x"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2001.00504.x"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2001.00563.x"},{"key":"e_1_2_8_21_2","article-title":"Comparative study of muscular strength and trophism in healthy subjects and haemophilic patients","volume":"10","author":"Querol F","year":"2004","journal-title":"Haemophilia"},{"key":"e_1_2_8_22_2","first-page":"132","article-title":"Bleed frequency, proprioception and isometric muscle strength in haemophilic arthropathy","volume":"10","author":"Krishnamurthy R","year":"2004","journal-title":"Haemophilia"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2005.01116.x"},{"issue":"2","key":"e_1_2_8_24_2","article-title":"Five\u2010year follow\u2010up study on muscle strength of the knee extensor and flexor muscles in hemophiliacs","volume":"12","author":"Ohmine S","year":"2006","journal-title":"Haemophilia"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01613.x"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02200.x"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01860.x"},{"key":"e_1_2_8_28_2","first-page":"45","volume-title":"37th Hemophilia Symposium Hamburg 2006","author":"Herbsleb M","year":"2008"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2009.02112.x"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2002.00640.x"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.324.7351.1417"},{"key":"e_1_2_8_32_2","volume-title":"Measuring Health. 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