{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T23:22:42Z","timestamp":1776381762235,"version":"3.51.2"},"reference-count":43,"publisher":"Wiley","issue":"s4","license":[{"start":{"date-parts":[[2012,6,25]],"date-time":"2012-06-25T00:00:00Z","timestamp":1340582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold> von Willebrand disease (VWD) is the most common inherited bleeding disorder, but variable severity and several classification types mean that diagnosis is often not straightforward. In many countries, the assays are not readily available and\/or are not well standardized. The latest methods and the basis of VWD are discussed here, together with information from the international quality assessment programme (IEQAS). Factor XIII deficiency is a rare, but important bleeding disorder, which may be missed or diagnosed late. A discussion and update on this diagnosis is considered in the final section of our review.<\/jats:p>","DOI":"10.1111\/j.1365-2516.2012.02830.x","type":"journal-article","created":{"date-parts":[[2012,6,25]],"date-time":"2012-06-25T13:34:37Z","timestamp":1340631277000},"page":"66-72","source":"Crossref","is-referenced-by-count":25,"title":["Difficulties and pitfalls in the laboratory diagnosis of bleeding disorders"],"prefix":"10.1111","volume":"18","author":[{"given":"P. H. B.","family":"BOLTON\u2010MAGGS","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. J.","family":"FAVALORO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"HILLARP","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"JENNINGS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. P.","family":"KOHLER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,6,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1281028"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1653684"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107464"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1651343"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.02146.x"},{"key":"e_1_2_6_7_2","first-page":"178","article-title":"Lower limit of assay sensitivity: an under\u2010recognised and significant problem in von Willebrand disease identification and classification","volume":"21","author":"Favaloro EJ","year":"2008","journal-title":"Clin Lab Sci"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH06-12-0693"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.04123.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.04029.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e32834a7e01"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198005083021902"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1066019"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1657727"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04460.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-299016"},{"key":"e_1_2_6_17_2","first-page":"FC04","article-title":"Development of a new functional assay for von Willebrand factor binding to platelet GP1a that does not require ristocetin","volume":"30","author":"Scneppenheim R","year":"2010","journal-title":"Hamostaseologie"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03594.x"},{"key":"e_1_2_6_19_2","first-page":"P07","article-title":"Evaluation of a new VWF activity assay based on GP1ba in the absence of ristocetin","volume":"30","author":"Patzke J","year":"2010","journal-title":"Hamostaseologie"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1619057"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-947865"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPH5JK4ONENPAE"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(86)90150-7"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/111.3.418"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH10-06-0360"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1613768"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1000364"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01933.x"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.1996.tb00009.x"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05829.x"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1281048"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1281047"},{"key":"e_1_2_6_33_2","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1055\/s-0037-1615375","article-title":"Assays for von Willebrand factor functional activity: a UK NEQAS survey. National External Quality Assessment Scheme","volume":"80","author":"Preston FE","year":"1998","journal-title":"Thromb Haemost"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2004.00944.x"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1653750"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1538-7836.2003.00469.x"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00016.2010"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a021336"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-11-253062"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1999.01648.x"},{"key":"e_1_2_6_41_2","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1160\/TH05-06-0388","article-title":"Characterisation of six novel A\u2010subunit mutations leading to congenital factor XIII deficiency and molecular analysis of the first diagnosed patient with this rare bleeding disorder","volume":"95","author":"Schroeder V","year":"2006","journal-title":"Thromb Haemost"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1225765"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04315.x"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-02-0788"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2516.2012.02830.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2516.2012.02830.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T03:15:09Z","timestamp":1694574909000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2516.2012.02830.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,25]]},"references-count":43,"journal-issue":{"issue":"s4","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1111\/j.1365-2516.2012.02830.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2516.2012.02830.x","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,25]]}}}