{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:58:12Z","timestamp":1761541092480},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,5,28]],"date-time":"2012-05-28T00:00:00Z","timestamp":1338163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The Malignancy in Haemophilia Workshop Group convened a consensus working group of haematologists and oncologists to review topics related to malignancy in haemophilia. The treatment of malignant disease in this population is increasingly relevant as both outcome and lifespan continue to improve. Although adequate guidance exists for control of spontaneous bleeding episodes and of haemostasis in general surgery, information for management of haemostasis in patients with various malignancies is sparse. To date, no clinical guidelines exist for management of complex bleeding problems, diagnosis, therapy and follow\u2010up of malignancies in haemophilia. Furthermore, it remains unclear whether or not morbidity and mortality outcomes associated with malignancies are affected by haemophilia or by its treatment. Through presentation of five malignancies \u2013 prostate cancer, colorectal cancer, acute leukaemia, bladder cancer and hepatocellular carcinoma \u2013 important issues are highlighted, such as risk from bleeding as a symptom of malignancy; risks from invasive screenings and how these should be handled in haemophilic individuals; the implications of chemotherapy and treatment schedules, bone marrow suppression, radiotherapy, or surgery; and the likelihood of an interaction between treatment for haemophilia and malignancy outcomes. Ultimately, the aim is to establish consensus guidelines to direct and harmonize future treatment policy for malignant disease in the haemophilic population.<\/jats:p>","DOI":"10.1111\/j.1365-2516.2012.02846.x","type":"journal-article","created":{"date-parts":[[2012,5,28]],"date-time":"2012-05-28T04:22:24Z","timestamp":1338178944000},"page":"664-671","source":"Crossref","is-referenced-by-count":14,"title":["Malignant disease in the haemophilic population: moving towards a management consensus?"],"prefix":"10.1111","volume":"18","author":[{"given":"J.","family":"Astermark","sequence":"first","affiliation":[{"name":"Centre for Thrombosis and Hemostasis, Sk\u00e5ne University Hospital Malm\u00f6 Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Makris","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Science University of Sheffield, Royal Hallamshire Hospital Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Mauser\u2010Bunschoten","sequence":"additional","affiliation":[{"name":"Van Creveldkliniek and Hematology University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Nemes","sequence":"additional","affiliation":[{"name":"National Haemophilia Centre and Haemostasis Department State Health Centre Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"D'oiron","sequence":"additional","affiliation":[{"name":"Haemophilia Centre, AP\u2010HP Bic\u00eatre Hospital, Paris\u2010XI University Le Kremlin\u2010Bic\u00eatre Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Oldenburg","sequence":"additional","affiliation":[{"name":"Institute of Experimental Hematology and Transfusion Medicine, University Clinic Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Ingerslev","sequence":"additional","affiliation":[{"name":"Kings College London School of Medicine London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The Malignancy in Haemophilia Workshop Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,5,28]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-10-050435"},{"volume-title":"JNCI Cancer Spectrum","author":"IARC Worldwide Cancer Incidence Statistics\u2014Prostate","key":"e_1_2_15_3_1"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.674"},{"volume-title":"SEER Cancer Statistics Review, 1975\u20132004","year":"2007","author":"Ries LAG","key":"e_1_2_15_5_1"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20408"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-007-9066-9"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0448"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.11.975"},{"key":"e_1_2_15_10_1","unstructured":"DawsonNA.Overview of treatment for advanced prostate cancer.http:\/\/www.uptodate.com\/contents\/screening-for-prostate-cancer?source=see_link&anchor=H25#H25. 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