{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T22:13:27Z","timestamp":1765232007623},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,5,30]],"date-time":"2012-05-30T00:00:00Z","timestamp":1338336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Multiple factors place adults with haemophilia at risk for depression. Health outcomes can be compromised in depressed patients secondary to increased risk taking behaviour and poor compliance with treatment recommendations. To assess the prevalence and risk factors associated with depression in adult patients with haemophilia treated at a haemophilia treatment centre. Adults with haemophilia were screened for depression during their annual clinic visit using the Patient Health Questionnaire 9 (<jats:styled-content style=\"fixed-case\">PHQ<\/jats:styled-content>\u20109), a validated tool for depression screening in adults. Depression was defined as a <jats:styled-content style=\"fixed-case\">PHQ<\/jats:styled-content>\u20109 score\u00a0\u2265\u00a05. Risk factors associated with depression were collected by chart review and correlated with depression scores. A total of 41 adult patients consented to the study and 37% met criteria for depression. Fifty\u2010three per cent of patients with depression reported moderate to severe symptoms of depression (<jats:styled-content style=\"fixed-case\">PHQ<\/jats:styled-content>\u20109 score &gt;10). Seventy\u2010six per cent of patients with depression reported suffering functional impairment due to their depressive symptoms. Lack of social support and unemployment were significantly associated with higher <jats:styled-content style=\"fixed-case\">PHQ<\/jats:styled-content>\u20109 scores (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04 and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01 respectively). Adult patients with haemophilia have a high prevalence of depression. The addition of depression screening to the comprehensive care of adults with haemophilia may result in improved overall health outcomes and treatment adherence.<\/jats:p>","DOI":"10.1111\/j.1365-2516.2012.02863.x","type":"journal-article","created":{"date-parts":[[2012,5,30]],"date-time":"2012-05-30T07:20:35Z","timestamp":1338362435000},"page":"868-874","source":"Crossref","is-referenced-by-count":57,"title":["Prevalence of depression in adults with haemophilia"],"prefix":"10.1111","volume":"18","author":[{"given":"M.","family":"Iannone","sequence":"first","affiliation":[{"name":"Arizona Hemophilia and Thrombosis Treatment Center Arizona Cancer Center Tucson AZ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Pennick","sequence":"additional","affiliation":[{"name":"Arizona Hemophilia and Thrombosis Treatment Center Arizona Cancer Center Tucson AZ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Tom","sequence":"additional","affiliation":[{"name":"Arizona Hemophilia and Thrombosis Treatment Center Arizona Cancer Center Tucson AZ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Cui","sequence":"additional","affiliation":[{"name":"Arizona Hemophilia and Thrombosis Treatment Center Arizona Cancer Center Tucson AZ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Arizona Hemophilia and Thrombosis Treatment Center Arizona Cancer Center Tucson AZ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Weihs","sequence":"additional","affiliation":[{"name":"Arizona Hemophilia and Thrombosis Treatment Center Arizona Cancer Center Tucson AZ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. T.","family":"Stopeck","sequence":"additional","affiliation":[{"name":"Arizona Hemophilia and Thrombosis Treatment Center Arizona Cancer Center Tucson AZ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,5,30]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"989","article-title":"Mental health in the United States: health risk behaviors and conditions among persons with depression \u2013 New Mexico, 2003","volume":"54","author":"Centers for Disease Control and Prevention (CDC)","year":"2005","journal-title":"Morb Mortal Wly Rep"},{"key":"e_1_2_9_3_1","first-page":"A14","article-title":"The vital link between chronic disease and depressive disorders","volume":"2","author":"Chapman D","year":"2005","journal-title":"Prev Chronic Dis"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2008.09.012"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2008.09.007"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/ewjm.175.5.292"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/ewjm.172.2.124"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.22.2836"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01444.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pec.2007.06.006"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0738-3991(87)90097-8"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(75)90028-8"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2003.00807.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01684.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.1999.00347.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2000.00358.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2002.00581.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2001.00476.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2005.07.003"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.2001.016009606.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199603000-00003"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlr.0000127998.89246.ef"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.18.1737"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1003955"},{"key":"e_1_2_9_25_1","first-page":"1253","article-title":"Diagnosis and management of depression in primary care: a clinical update and review","volume":"167","author":"Remick R","year":"2002","journal-title":"Can Med Assoc J"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2516.2012.02863.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2516.2012.02863.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T09:34:33Z","timestamp":1698658473000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2516.2012.02863.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,30]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1111\/j.1365-2516.2012.02863.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2516.2012.02863.x","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,30]]}}}