{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:44:25Z","timestamp":1793742265846,"version":"4.6.1"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,7,5]],"date-time":"2012-07-05T00:00:00Z","timestamp":1341446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Evaluation of prophylactic treatment of haemophilia requires sensitive methods. To design and test a new magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) scale for haemophilic arthropathy, two scales of a combined <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> scoring scheme were merged into a single scale which includes soft tissue and osteochondral subscores. Sixty\u2010one joint <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>'s of 46 patients with haemophilia were evaluated by four radiologists using the new and older scales. Forty\u2010six of the joints were evaluated using two X\u2010ray scales. For all <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> scores, interreader agreement and correlations with X\u2010ray scores and lifetime number of haemarthroses were analysed. The interreader agreement intraclass correlation coefficient was 0.82, 0.89 and 0.88 for the soft tissue and osteochondral subscores and the total score, as evaluated according to the new <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> scale, compared to 0.80 and 0.89 as for the older scales. The total score and osteochondral subscore according to the new scale, as well as scores according to the older scales were correlated (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) with number of haemarthroses (Spearman correlation 0.35\u20130.68) and with the X\u2010ray scores (Spearman correlation 0.40\u20130.76), but no correlation (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05) was found between the soft tissue subscore of the new <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> scale and the X\u2010ray scores. The new <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> scale is simpler to apply than the older and has similar reader reliability and correlation with lifetime number of haemarthroses, and by separating soft tissue and osteochondral changes it gives additional information. The new scale is useful for analyses of early and moderate stages of arthropathy, and may help to evaluate prophylactic haemophilia treatment.<\/jats:p>","DOI":"10.1111\/j.1365-2516.2012.02883.x","type":"journal-article","created":{"date-parts":[[2012,7,6]],"date-time":"2012-07-06T05:31:43Z","timestamp":1341552703000},"page":"962-970","source":"Crossref","is-referenced-by-count":130,"title":["An MRI scale for assessment of haemophilic arthropathy from the International Prophylaxis Study Group"],"prefix":"10.1111","volume":"18","author":[{"given":"B.","family":"Lundin","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Lund, Division of Diagnostic Radiology and Center for Medical Imaging and Physiology Lund University, Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. L.","family":"Manco\u2010Johnson","sequence":"additional","affiliation":[{"name":"Department of Radiology and Hemophilia &amp; Thrombosis Center University of Colorado  Denver CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. M.","family":"Ignas","sequence":"additional","affiliation":[{"name":"Child Health Evaluative Sciences The Hospital for Sick Children  Toronto  Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Moineddin","sequence":"additional","affiliation":[{"name":"University of Toronto Public Health, Family and Community Medicine  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. S.","family":"Blanchette","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology, The Hospital for Sick Children and Department of Pediatrics University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. L.","family":"Dunn","sequence":"additional","affiliation":[{"name":"Aflac Cancer Center and Blood Disorders Service, Children's Healthcare of Atlanta Emory University School of Medicine  Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. V.","family":"Gibikote","sequence":"additional","affiliation":[{"name":"Department of Radiology Christian Medical College  Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. N.","family":"Keshava","sequence":"additional","affiliation":[{"name":"Department of Radiology Christian Medical College  Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Ljung","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Lund University Sk\u00e5ne University Hospital  Malm\u00f6\u2010Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Manco\u2010Johnson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and the Hemophilia &amp; Thrombosis Center University of Colorado  Denver CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. F.","family":"Miller","sequence":"additional","affiliation":[{"name":"St. Jude Children's Research Hospital  Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. E.","family":"Rivard","sequence":"additional","affiliation":[{"name":"CHU Sainte Justine University of Montreal  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. S.","family":"Doria","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The International Prophylaxis Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01268.x"},{"key":"e_1_2_9_3_1","first-page":"691","article-title":"Modern treatment of haemophilia","volume":"73","author":"Berntorp E","year":"1995","journal-title":"Bull World Health Organ"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2002.00631.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1992.tb00546.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1990.tb00291.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2004.01047.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2004.00978.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1994.tb00815.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067659"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2004.00902.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2005.01061.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2000.00383.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2003.00702.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003300101078"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2000.00406.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2002.00585.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102516.2011.02513.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197759030-00001"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-198006000-00018"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01750.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2005.01049.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01208.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01310.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2005.01097.x"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01602.x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01778.x"},{"key":"e_1_2_9_28_1","volume-title":"The MRI Atlas of Hemophilic Arthropathy","author":"Nuss R","year":"2002"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.328.7441.702"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02669.x"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2516.2012.02883.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2516.2012.02883.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T09:35:04Z","timestamp":1698658504000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2516.2012.02883.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,5]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1111\/j.1365-2516.2012.02883.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2516.2012.02883.x","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,5]]}}}