{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:26:42Z","timestamp":1757705202872},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,4,3]],"date-time":"2007-04-03T00:00:00Z","timestamp":1175558400000},"content-version":"vor","delay-in-days":4444,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[1995,2]]},"abstract":"<jats:p>Six cases of hydatidiform mole associated with normal chorionic villi and a normal embryo\/fetus (in five cases) were investigated with interphase cytogenetic and DNA cytometric analyses for diagnostic purposes. DNA probes specific for the pericentromeric regions of chromosomes 1 and X and for the long arm of chromosome Y were used. In four cases a dizygotic twin pregnancy could be proven. In these cases, the histologically normal chorionic villi showed an XY DNA\u2010diploid pattern, consistent with a normal male conceptus, and the molar chorionic villi a XX pattern. In the other two cases an identical sex chromosomal pattern was found in the normal and in the molar villi (XX\/XX and XY\/XY respectively). In all six cases the molar placental tissues showed prominent trophoblastic hyperplasia with DNA\u2010polyploidy, consistent with a complete hydatidiform mole. In two cases persistent gestational trophoblastic disease developed. It is emphasized that twin pregnancies composed of a normal conceptus and a complete mole have a relatively high risk for the development of persistent trophoblastic disease and therefore, should be carefully differentiated from triploid partial moles with a relatively low risk of persistent gestational trophoblastic disease. These case reports indicate that additional interphase cytogenetic and DNA cytometric analyses are useful in this differential diagnosis.<\/jats:p>","DOI":"10.1111\/j.1365-2559.1995.tb00641.x","type":"journal-article","created":{"date-parts":[[2007,4,3]],"date-time":"2007-04-03T14:36:58Z","timestamp":1175611018000},"page":"123-129","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Complete hydatidiform mole in twin pregnancy"],"prefix":"10.1111","volume":"26","author":[{"given":"C.A. 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