{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:50:17Z","timestamp":1790729417165,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,6,2]],"date-time":"2004-06-02T00:00:00Z","timestamp":1086134400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:p><jats:bold>Aims and methods:\u2002<\/jats:bold> Pulmonary parenchymal disease is common in patients with connective tissue disorders (CTDs). However, most reports precede recognition of non\u2010specific interstitial pneumonia (NSIP). We have therefore reviewed 54 lung biopsies from 37 patients with polymyositis\/dermatomyositis (PM\/DM) (<jats:italic>n<\/jats:italic>\u2003=\u200313), Sj\u00f6gren's syndrome (<jats:italic>n<\/jats:italic>\u2003=\u20035), rheumatoid arthritis (<jats:italic>n<\/jats:italic>\u2003=\u200317) and systemic lupus erythematosus (SLE) (<jats:italic>n<\/jats:italic>\u2003=\u20032) to assess the overall and relative frequencies of patterns of interstitial pneumonia and their impact on prognosis.<\/jats:p><jats:p><jats:bold>Results and conclusions:\u2002<\/jats:bold> NSIP was the most common pattern with an overall biopsy prevalence of 39% and patient prevalence of 41%. There was variation in prevalence between individual CTDs, with PM\/DM commonly showing organizing pneumonia (<jats:italic>n<\/jats:italic>\u2003=\u20035), rheumatoid arthritis showing follicular bronchiolitis (<jats:italic>n<\/jats:italic>\u2003=\u20036) and Sj\u00f6gren's syndrome showing chronic bronchiolitis (<jats:italic>n<\/jats:italic>\u2003=\u20034). These patterns presented either separately or in association with NSIP, occasionally with different patterns in biopsies from separate lobes. Only four patients showed a pattern of usual interstitial pneumonia (UIP): two with rheumatoid arthritis and one each with PM\/DM and SLE. Overall mortality was 24%, the most frequently associated pattern being fibrotic NSIP (<jats:italic>n<\/jats:italic>\u2003=\u20035). In nine cases, pulmonary presentation preceded the systemic manifestation of the CTDs. When patients with CTDs present with chronic interstitial lung disease, the most common pattern is NSIP, although there is variation in pattern prevalence between individual disorders and patterns of interstitial pneumonia frequently overlap. These data suggest a different biology for intestitial pneumonias in CTDs when compared with the idiopathic interstitial pneumonias where UIP is the most common pattern. Mortality is similar to that seen in idiopathic NSIP and, coupled with pulmonary presentation occurring prior to the systemic manifestation of disease, this may have a bearing on the origin of some cases of putative idiopathic NSIP.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2004.01896.x","type":"journal-article","created":{"date-parts":[[2004,12,25]],"date-time":"2004-12-25T17:32:39Z","timestamp":1103995959000},"page":"585-596","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":267,"title":["Variations in histological patterns of interstitial pneumonia between connective tissue disorders and their relationship to prognosis"],"prefix":"10.1111","volume":"44","author":[{"given":"D","family":"Tansey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A U","family":"Wells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T V","family":"Colby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Ip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Nikolakoupolou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R M","family":"Du Bois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D M","family":"Hansell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A G","family":"Nicholson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,6,2]]},"reference":[{"key":"e_1_2_11_2_2","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S0272-5231(21)00660-2","article-title":"Pulmonary manifestations of the collagen vascular diseases","volume":"10","author":"Wiedemann HP","year":"1989","journal-title":"Clin. Chest Med."},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(90)90001-L"},{"key":"e_1_2_11_4_2","first-page":"168","volume-title":"Surgical pathology of non\u2010neoplastic lung disease.","author":"Katzenstein A\u2010L","year":"1997"},{"key":"e_1_2_11_5_2","first-page":"137","volume-title":"Interstitial lung diseases.","author":"Wells AU.","year":"2001"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10794"},{"key":"e_1_2_11_7_2","first-page":"1336","article-title":"Pulmonary involvement in polymyositis and in dermatomyositis","volume":"25","author":"Marie I","year":"1998","journal-title":"J. Rheumatol."},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(69)90044-8"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/sarh.2002.50012"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/141.3.727"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02030506"},{"key":"e_1_2_11_12_2","first-page":"770","article-title":"Lung biopsy in rheumatoid arthritis","volume":"131","author":"Yousem SA","year":"1985","journal-title":"Am. Rev. Respir. Dis."},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/144.3_Pt_1.706"},{"key":"e_1_2_11_14_2","first-page":"277","article-title":"ATS\/ERS Consensus statement of idiopathic interstitial pneumonias","volume":"265","author":"Travis WD","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199402000-00003"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1987.135.4.880"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2106012"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.3.281"},{"key":"e_1_2_11_19_2","first-page":"121","article-title":"The major histopathologic pattern of pulmonary fibrosis in scleroderma is nonspecific interstitial pneumonia","volume":"19","author":"Kim DS","year":"2002","journal-title":"Sarcoidosis Vasc. Diffuse Lung Dis."},{"key":"e_1_2_11_20_2","volume-title":"Rheumatology.","author":"Hochberg MC","year":"2003"},{"key":"e_1_2_11_21_2","first-page":"10","article-title":"Histopathological approach to patterns of interstitial pneumonia in patient with connective tissue disorders","volume":"19","author":"Nicholson AG","year":"2002","journal-title":"Sarcoidosis Vasc. Diffuse Lung Dis."},{"key":"e_1_2_11_22_2","first-page":"102","article-title":"Interstitial lung disease in dermatomyositis: clinicopathological study","volume":"14","author":"Takizawa H","year":"1987","journal-title":"J. Rheumatol."},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.70.3.354"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00063198-200009000-00007"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-200001000-00003"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.3109\/15513818709177110"},{"key":"e_1_2_11_27_2","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0889-857X(21)00230-1","article-title":"Pleuropulmonary manifestations of systemic lupus erythematosus","volume":"20","author":"Orens JB","year":"1994","journal-title":"Rheum. Dis. Clin. North Am."},{"key":"e_1_2_11_28_2","first-page":"2254","article-title":"Bronchiolitis obliterans organizing pneumonia as an initial manifestation in patients with systemic lupus erythematosus","volume":"24","author":"Min JK","year":"1997","journal-title":"J. Rheumatol."},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.1177\/096120339500400217"},{"key":"e_1_2_11_30_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.7.2103110"},{"key":"e_1_2_11_31_2","first-page":"645","volume-title":"Interstitial lung disease.","author":"King TE.","year":"1998"},{"key":"e_1_2_11_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197601000-00005"},{"key":"e_1_2_11_33_2","first-page":"969","article-title":"Interstitial pneumonia preceding systemic sclerosis","volume":"36","author":"Imokawa S","year":"1998","journal-title":"Nihon Kokyuki Gakkai Zasshi"},{"key":"e_1_2_11_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005382-199623000-00002"},{"key":"e_1_2_11_35_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.169.1.9207505"},{"key":"e_1_2_11_36_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.9.2103074"},{"key":"e_1_2_11_37_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197804132981501"},{"key":"e_1_2_11_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)65379-8"},{"key":"e_1_2_11_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(90)90002-M"},{"key":"e_1_2_11_40_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.54.11.1009"},{"key":"e_1_2_11_41_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.94.2.438"},{"key":"e_1_2_11_42_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005382-199707000-00009"},{"key":"e_1_2_11_43_2","first-page":"A299","article-title":"Clinical\u2010radiological\u2010pathological features of lung diseases in patients with primary Sj\u00f6gren's syndrome","volume":"167","author":"Ito I","year":"2003","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"e_1_2_11_44_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-132-12-200006200-00004"},{"key":"e_1_2_11_45_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.1.9704130"},{"key":"e_1_2_11_46_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200001000-00003"},{"key":"e_1_2_11_47_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.98.12051010"},{"key":"e_1_2_11_48_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.6.2003049"},{"key":"e_1_2_11_49_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.3.9903021"},{"key":"e_1_2_11_50_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00182002"},{"key":"e_1_2_11_51_2","doi-asserted-by":"publisher","DOI":"10.1159\/000050485"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2559.2004.01896.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2559.2004.01896.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T06:34:21Z","timestamp":1697178861000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2559.2004.01896.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2004,6]]}},"alternative-id":["10.1111\/j.1365-2559.2004.01896.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2559.2004.01896.x","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,6]]},"assertion":[{"value":"2004-06-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}