{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T12:20:46Z","timestamp":1774441246998,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,11,29]],"date-time":"2004-11-29T00:00:00Z","timestamp":1101686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:p><jats:bold>Aims:\u2002<\/jats:bold> To determine whether a micropapillary component is a prognostic predictor, with particular reference to nodal micrometastasis, in patients with stage I lung adenocarcinomas.<\/jats:p><jats:p><jats:bold>Methods and results:\u2002<\/jats:bold> Thirty\u2010five cases with stage I lung adenocarcinomas, obtained from lobectomies or pneumonectomies, and 434 dissected hilar and mediastinal lymph nodes, were retrospectively reviewed. A micropapillary component and nodal micrometastasis were found in 16 (45.7%) and 14 (40%) of the 35 cases, respectively, with nodal micrometastasis in 24 (5.5%) of the 434 lymph nodes, in an immunohistochemical study using an anti\u2010cytokeratin antibody. Ten (62.5%) of the 16 cases with a micropapillary component, and four (21.1%) of the remaining 19 cases, showed nodal micrometastases (<jats:italic>P\u2003=<\/jats:italic>\u20030.014). Kaplan\u2013Meier survival curves demonstrated that there was no significant difference between the cases with and without a micropapillary component (<jats:italic>P\u2003=<\/jats:italic>\u20030.28). However, the 5\u2003years' survival of the cases with and without nodal micrometastases were 71.4% and 35.7%, respectively (<jats:italic>P\u2003=<\/jats:italic>\u20030.03).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> A micropapillary component may be a manifestation of aggressive behaviour, as shown by frequent micrometastasis, for stage I lung adenocarcinomas.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2004.01953.x","type":"journal-article","created":{"date-parts":[[2004,11,29]],"date-time":"2004-11-29T10:10:32Z","timestamp":1101723032000},"page":"580-586","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Relationship between micropapillary component and micrometastasis in the regional lymph nodes of patients with stage I lung adenocarcinoma"],"prefix":"10.1111","volume":"45","author":[{"given":"M S","family":"Roh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J I","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P J","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y S","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,11,29]]},"reference":[{"key":"e_1_2_15_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880399"},{"key":"e_1_2_15_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199412000-00005"},{"key":"e_1_2_15_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005392-199906000-00017"},{"key":"e_1_2_15_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199611000-00003"},{"key":"e_1_2_15_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200203000-00010"},{"key":"e_1_2_15_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200301000-00011"},{"key":"e_1_2_15_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199701000-00005"},{"key":"e_1_2_15_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(01)03376-8"},{"key":"e_1_2_15_10_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.11.011"},{"key":"e_1_2_15_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-60049-4"},{"key":"e_1_2_15_12_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.111.6.1710"},{"key":"e_1_2_15_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(96)70044-2"},{"key":"e_1_2_15_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21979"},{"key":"e_1_2_15_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200104000-00001"},{"key":"e_1_2_15_16_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.1.19"},{"key":"e_1_2_15_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/85.6.493"},{"key":"e_1_2_15_18_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1994.12.9.1827"},{"key":"e_1_2_15_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1092-9134(02)91216-5"},{"key":"e_1_2_15_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(11)80745-4"},{"key":"e_1_2_15_21_2","first-page":"499","article-title":"Infiltrating micropapillary carcinoma of the breast","volume":"12","author":"Middleton LP","year":"1999","journal-title":"Mod. 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