{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:07:24Z","timestamp":1790665644402,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,11,29]],"date-time":"2004-11-29T00:00:00Z","timestamp":1101686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:p><jats:bold>Aims:\u2002<\/jats:bold> Mediastinal large B\u2010cell lymphoma (MLBCL) is a subtype of diffuse large B\u2010cell lymphoma (DLBCL) in the WHO classification with peculiar features, such as female prevalence, young patient age and bulky presentation. It shows a B\u2010cell phenotype with variable expression of surface immunoglobulin, negative CD21 and CD10 and positive CD30 in a large number of cases. An origin from activated thymic B cells has been suggested in several studies. A subpopulation of large, dendritic cells (asteroid cells) strongly expressing CD23 has been identified amongst thymic B cells and these could represent the normal cellular counterpart for this type of primary mediastinal large cell lymphoma.<\/jats:p><jats:p><jats:bold>Methods and results:\u2002<\/jats:bold> To explore this possibility, we immunostained 24 cases of primary mediastinal lymphomas and 100 cases of non\u2010mediastinal, nodal and extranodal, DLBCLs for CD23 in routinely processed paraffin\u2010embedded tissues.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Our results show that a vast majority (70%) of mediastinal lymphomas strongly express CD23 whilst the same antigen is expressed in only 15% of non\u2010mediastinal nodal DLBCLs and 9% of non\u2010mediastinal extranodal DLBCLs. These results support the hypothesis that most cases of MLBCL arise from activated dendritic thymic B cells. We also suggest that CD23 should be included in the panel of antibodies currently used to characterize this subtype of DLBCL.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2004.01969.x","type":"journal-article","created":{"date-parts":[[2004,11,29]],"date-time":"2004-11-29T10:10:32Z","timestamp":1101723032000},"page":"619-624","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["CD23 expression in mediastinal large B\u2010cell lymphomas"],"prefix":"10.1111","volume":"45","author":[{"given":"M","family":"Calaminici","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Piper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A M","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A J","family":"Norton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,11,29]]},"reference":[{"key":"e_1_2_10_2_2","first-page":"175","volume-title":"WHO, Pathology & genetics, tumours of haematopoietic and lymphoid tissue.","author":"Jaffe E","year":"2001"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199607000-00012"},{"key":"e_1_2_10_4_2","first-page":"241","article-title":"CD30 expression is common in mediastinal large B\u2010cell lymphoma","volume":"112","author":"Higgins J","year":"1999","journal-title":"Haematopathology"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)92622-5"},{"key":"e_1_2_10_6_2","first-page":"735","article-title":"Discordant expression of immunoglobulin and its associated molecule mb\u20101\/CD79a is frequently found in mediastinal large B\u2010cell lymphoma","volume":"146","author":"Kanavaros P","year":"1995","journal-title":"Am. 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