{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T10:21:15Z","timestamp":1763806875986},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,3,23]],"date-time":"2005-03-23T00:00:00Z","timestamp":1111536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:p><jats:bold>Aims<\/jats:bold> :\u2002To examine the clinical and pathological characteristics of supratentorial primitive neuroectodermal tumours (PNETs) in a retrospective series of 18 patients, according to the strict definition of the World Health Organization classification of tumours that excludes other types of malignant embryonal tumours of the brain.<\/jats:p><jats:p><jats:bold>Methods and results<\/jats:bold> :\u2002Eleven children and seven adults with supratentorial PNETs were diagnosed between 1993 and 2002 and their medical records were reviewed. An immunohistochemical study was performed on formalin\u2010fixed paraffin\u2010embedded tissue of 18 primary tumours and five recurrences with antibodies for neuronal (neuron specific enolase, synaptophysin, neurofilament, chromogranin A), epithelial [epithelial membrane antigen (EMA), cytokeratin], glial [glial fibrillary acidic protein (GFAP)], muscle (desmin, h\u2010caldesmon, \u03b1\u2010smooth muscle actin, myogenin) differentiation and with two anti\u2010CD99 antibodies. All tumours showed at least one neuronal marker except chromogranin A; a variable number of cells were GFAP+ or EMA+ in 18\/23 tumours. Six primary tumours and one recurrence were positive for cytokeratin and\/or one muscle antigen except myogenin. CD99 was observed in 33% of the cases. The mean duration of overall survival was 20\u2003months. The estimated overall survival rates were 61% at 1\u2003year, 29% at 2\u2003years, and 18% at 3\u2003years. Two factors of poor prognosis were identified by univariate analysis: a positive cerebrospinal fluid cytology at diagnosis and the absence of complete resection. No distinct immunophenotype was statistically related to survival.<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold> :\u2002A multidirectional differentiation is a frequent event in supratentorial PNETs but has no apparent influence on the outcome of this aggressive neoplasm.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2005.02101.x","type":"journal-article","created":{"date-parts":[[2005,3,23]],"date-time":"2005-03-23T17:14:26Z","timestamp":1111598066000},"page":"403-412","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Supratentorial primitive neuroectodermal tumours of the brain: multidirectional differentiation does not influence prognosis. A clinicopathological report of 18 patients"],"prefix":"10.1111","volume":"46","author":[{"given":"S","family":"Vis\u00e9e","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Soltner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X","family":"Rialland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M C","family":"Machet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Loussouarn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Milinkevitch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Pasco\u2010Papon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Mercier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M C","family":"Rousselet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,3,23]]},"reference":[{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00165168"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020207902659"},{"key":"e_1_2_13_4_2","volume-title":"World Health Organisation classification of tumours: pathology and genetics of tumours of the nervous system.","author":"Kleihues P","year":"2000"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198301000-00001"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-3676-4_3"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410390410"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990701)86:1<142::AID-CNCR20>3.0.CO;2-Y"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.10121"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1995.13.7.1687"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00165520"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000028717"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000501)88:9<2189::AID-CNCR27>3.0.CO;2-G"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.1277"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.3.842"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000121292"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/415436a"},{"key":"e_1_2_13_18_2","first-page":"19","article-title":"Computed tomography of primitive neuroectodermal tumors","volume":"4","author":"Ganti SR","year":"1983","journal-title":"Am. J. Neuroradiol."},{"key":"e_1_2_13_19_2","first-page":"170","article-title":"Understanding the radiology of intracranial primitive neuroectodermal tumors from a pathological perspective: a review","volume":"13","author":"Robles HA","year":"1992","journal-title":"Semin. Ultrasound CT MR"},{"key":"e_1_2_13_20_2","first-page":"228","article-title":"Primitive neuroectodermal tumors of the cerebrum. A histological and immunohistochemical study of 10 cases","volume":"7","author":"Grant JW","year":"1988","journal-title":"Clin. Neuropathol."},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.3109\/01913128809032233"},{"key":"e_1_2_13_22_2","first-page":"498","article-title":"Primitive neuroectodermal tumors of the central nervous system. Patterns of expression of neuroendocrine markers, and all classes of intermediate filament proteins","volume":"62","author":"Gould VE","year":"1990","journal-title":"Lab. Invest."},{"key":"e_1_2_13_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(90)90223-R"},{"key":"e_1_2_13_24_2","first-page":"635","article-title":"Molecular markers of primitive neuroectodermal tumors and other pediatric central nervous system tumors. Monoclonal antibodies to neuronal and glial antigens distinguish subsets of primitive neuroectodermal tumors","volume":"61","author":"Molenaar WM","year":"1989","journal-title":"Lab. Invest."},{"key":"e_1_2_13_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900715)66:2<273::AID-CNCR2820660214>3.0.CO;2-V"},{"key":"e_1_2_13_26_2","volume-title":"Russel and Rubinstein's pathology of tumors of the nervous system.","author":"Wikstrand CJ","year":"1998"},{"key":"e_1_2_13_27_2","doi-asserted-by":"publisher","DOI":"10.3109\/01913128609064199"},{"key":"e_1_2_13_28_2","first-page":"74","article-title":"Germ\u2010line and acquired mutations of INI1 in atypical teratoid and rhabdoid tumors","volume":"59","author":"Biegel JA","year":"1999","journal-title":"Cancer Res."},{"key":"e_1_2_13_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200405000-00013"},{"key":"e_1_2_13_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1092-9134(99)80022-7"},{"key":"e_1_2_13_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/00129039-200106000-00004"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2559.2005.02101.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2559.2005.02101.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T11:09:27Z","timestamp":1697195367000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2559.2005.02101.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3,23]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["10.1111\/j.1365-2559.2005.02101.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2559.2005.02101.x","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,3,23]]},"assertion":[{"value":"2005-03-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}