{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:01:30Z","timestamp":1790852490382,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,11,22]],"date-time":"2005-11-22T00:00:00Z","timestamp":1132617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:p><jats:bold>Aims<\/jats:bold> :\u2002To evaluate the caveolin\u20101 status of invasive ductal carcinoma and its correlation with other important parameters of breast carcinogenesis. Caveolin\u20101, the main structural protein of caveolae, is involved in the regulation of several intracellular signalling pathways and also functions as a tumour suppressor in breast carcinogenesis.<\/jats:p><jats:p><jats:bold>Methods and results<\/jats:bold> :\u2002One hundred and thirty cases of invasive ductal carcinomas with matched normal breast tissue were evaluated immunohistochemically for caveolin\u20101 expression. Using a tissue microarray, caveolin\u20101 expression was also correlated with the expression of other antigens such as eostrogen receptor, progesterone receptor, epidermal growth factor receptor (EGFR), HER2, \u03b2\u2010catenin, E\u2010cadherin, p53, Ki67 and with clinicopathological parameters. Immunohistochemical results showed strong expression of caveolin\u20101 in all normal breast epithelial cells, but a reduction of caveolin\u20101 expression in 56 cases (43.1%) of invasive ductal carcinoma. Furthermore, a statistically significant inverse correlation between caveolin\u20101 and EGFR and HER2 was noted (<jats:italic>P\u2003&lt;<\/jats:italic>\u20030.001).<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold> :\u2002Our results indicate a reduction in caveolin\u20101 expression in invasive ductal carcinoma of the breast, which supports <jats:italic>in vitro<\/jats:italic> studies of its role as a tumour suppressor. Caveolin\u20101 also shows an inverse correlation with EGFR and HER2, which fits with its function as a negative regulator of signal transduction.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2005.02303.x","type":"journal-article","created":{"date-parts":[[2006,3,30]],"date-time":"2006-03-30T09:15:44Z","timestamp":1143710144000},"page":"625-630","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Caveolin\u20101 is down\u2010regulated and inversely correlated with HER2 and EGFR expression status in invasive ductal carcinoma of the breast"],"prefix":"10.1111","volume":"47","author":[{"given":"S\u2010S","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J E","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y A","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y C","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u2010W","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00694752"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000163805"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.67.1.199"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00472-X"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.10.5419"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.0236"},{"key":"e_1_2_6_8_2","first-page":"5870","article-title":"Caveolin\u20101 levels are down\u2010regulated in human colon tumors, and ectopic expression of caveolin\u20101 in colon carcinoma cell lines reduces cell tumorigenicity","volume":"60","author":"Bender FC","year":"2000","journal-title":"Cancer Res."},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63010-6"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64031-X"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1201661"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1042\/BST0290494"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E02-08-0503"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602029"},{"key":"e_1_2_6_15_2","doi-asserted-by":"crossref","first-page":"30429","DOI":"10.1074\/jbc.272.48.30429","article-title":"Interaction of receptor tyrosine kinase, EGF\u2010R., with caveolins. Caveolin binding negatively regulates tyrosine and serine\/threonine kinase activities","volume":"272","author":"Couet J","year":"1997","journal-title":"J. Biol. 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