{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:32:51Z","timestamp":1770823971952,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,2,16]],"date-time":"2006-02-16T00:00:00Z","timestamp":1140048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:p><jats:bold>Aims<\/jats:bold> :\u2002To describe the clinical and pathological features of 10 further cases of fibroblastic polyps (FP), a recently described, distinctive type of colorectal mucosal polyp.<\/jats:p><jats:p><jats:bold>Methods and results<\/jats:bold> :\u2002The patients were seven women and three men with ages ranging from 44 to 63\u2003years. The lesions ranged in size from 2 to 4\u2003mm. Eight of the polyps were located in the sigmoid colon. Five cases were associated with hyperplastic polyps. Histologically, FP displayed bland, plump spindle cells with oval nuclei arranged as bundles parallel to the surface or as haphazardly orientated sheets with a focal periglandular or perivascular concentric arrangement. Eight polyps represented mixed fibroblastic\/hyperplastic polyps as they contained serrated (hyperplastic) crypts. Immunohistochemically, all cases were positive for vimentin and negative for desmin, smooth\u2010muscle actin, h\u2010caldesmon, S100 protein, c\u2010Kit, epithelial membrane antigen, cytokeratin AE1\/3, CD34, CD68, COX\u20102, and factor XIIIa. Ultrastructural examination supported the fibroblastic nature of the tumour cells.<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold> :\u2002FP is a distinctive type of benign mucosal colorectal polyp characterized by its distal location, small size, frequent association with hyperplastic polyps, distinct morphological appearance and typical immunonegativity for markers of specific differentiation. FP with serrated crypts (mixed fibroblastic\/hyperplastic polyp) represents a frequent variant of this lesion. Pathologists should recognize FP and discriminate it from other types of colorectal polyps.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2006.02357.x","type":"journal-article","created":{"date-parts":[[2006,2,16]],"date-time":"2006-02-16T16:02:23Z","timestamp":1140105743000},"page":"431-437","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Fibroblastic polyp of the colon: clinicopathological analysis of 10 cases with emphasis on its common association with serrated crypts"],"prefix":"10.1111","volume":"48","author":[{"given":"G M","family":"Groisman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Polak\u2010Charcon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H D","family":"Appelman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,2,16]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200403000-00010"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000141397.49460.12"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198803000-00001"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200401000-00013"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000141398.57084.6d"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1309\/N2TW-ENRB-1N1C-DWL0"},{"key":"e_1_2_8_8_2","first-page":"543","article-title":"Fascin, a sensitive new marker for Reed\u2013Sternberg cells of Hodgkin's disease. Evidence for a dendritic or B cell derivation?","volume":"150","author":"Pinkus GS","year":"1997","journal-title":"Am. J. Pathol."},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800294"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(91)90162-I"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004280000338"},{"key":"e_1_2_8_12_2","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1093\/ajcp\/55.3.377","article-title":"Smooth muscle hamartomas of the sigmoid colon: report of a case","volume":"55","author":"Goldstein HB","year":"1971","journal-title":"Am. J. Clin. Pathol."},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199407000-00012"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.10.11.871"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198112000-00004"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2559.2006.02357.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2559.2006.02357.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T17:03:25Z","timestamp":1697216605000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2559.2006.02357.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2,16]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["10.1111\/j.1365-2559.2006.02357.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2559.2006.02357.x","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,2,16]]},"assertion":[{"value":"2006-02-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}