{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:03:08Z","timestamp":1770822188701,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,2,16]],"date-time":"2006-02-16T00:00:00Z","timestamp":1140048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:p><jats:bold>Aim<\/jats:bold> :\u2002To evaluate clinical, biological and immunological features of patients with increased duodenal intraepithelial lymphocytes (IELs), and its relation to <jats:italic>Helicobacter pylori<\/jats:italic> (HP) and coeliac disease (CD).<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold> :\u2002We have studied all patients accrued over a 4\u2010year period with increased duodenal IELs. Those patients were recalled for biological and immunological evaluation and a second endoscopy.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> :\u2002Twenty\u2010three from a total of 639 patients were identified and 17 of them were included in the study. The median duodenal IEL count was 59 per 100 epithelial cells. Twelve (71%) patients were HP+; eight of them received HP eradication. At the second endoscopy the duodenal IEL count was significantly lower 2\u2003months after HP eradication (73 versus 28), while the IEL count was unchanged in those patients seronegative for HP (<jats:italic>n<\/jats:italic>\u2003=\u20035) or those in whom it was not eradicated (<jats:italic>n<\/jats:italic>\u2003=\u20034) (55 versus 55). No patient had coeliac antibodies, four expressed HLA\u2010DQ2, lower than in the general population, and the prevalence of CD was 2% (12\/639 patients).<\/jats:p><jats:p><jats:bold>Conclusion<\/jats:bold> :\u2002In some cases an increased duodenal IEL count may be due to an inappropriate host response to HP. HP screening and eradication should be considered before recommending a gluten\u2010free diet.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2006.02358.x","type":"journal-article","created":{"date-parts":[[2006,2,16]],"date-time":"2006-02-16T16:02:23Z","timestamp":1140105743000},"page":"417-423","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Duodenal intraepithelial lymphocytosis during <i>Helicobacter pylori<\/i> infection is reduced by antibiotic treatment"],"prefix":"10.1111","volume":"48","author":[{"given":"S","family":"Nahon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N Patey\u2010Mariaud","family":"De Serre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Lejeune","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u2010X","family":"Huchet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Lahmek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Lesgourgues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Traissac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Bodiguel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Adotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Tuszynski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Delas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,2,16]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.18.11.921"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001574-199309060-00011"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)91819-P"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.24056"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.31.1.32"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92234-S"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010729207320"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.55.6.424"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03812.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v111.pm8780564"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200301000-00006"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03744.x"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199902000-00003"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.4.495"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.55.5.393"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2000.00926.x"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1309\/5PRJ-CM0U-6KLD-6KCM"},{"key":"e_1_2_7_20_2","first-page":"1414","article-title":"Epidemiology, acquisition and transmission of Helicobacter pylori","volume":"50","author":"Megraud F","year":"2000","journal-title":"Rev. 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