{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T14:37:09Z","timestamp":1785681429807,"version":"3.56.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,3,28]],"date-time":"2006-03-28T00:00:00Z","timestamp":1143504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:p><jats:bold>Aims<\/jats:bold> :\u2002Pseudosarcomatous myofibroblastic proliferation of the genitourinary tract is rare and may develop after trauma or spontaneously. The aim of this study was to characterize further the clinicopathological features of these lesions and to examine their relationship to inflammatory myofibroblastic tumour (IMT).<\/jats:p><jats:p><jats:bold>Methods and results<\/jats:bold> :\u2002Twenty\u2010seven cases of pseudosarcomatous myofibroblastic proliferation were analysed. There were seven males and 20 females; median age was 37\u2003years (range 16\u201388). Most lesions were from the bladder (<jats:italic>n<\/jats:italic>\u2003=\u200321), while others were in the urethra, vulva, vagina, rectum and retrovesical space. Median tumour size was 30\u2003mm (range 6\u2013120\u2003mm). Seven cases (25%) had a history of prior trauma or surgery. Three cases recurred locally but not destructively. The tumours had fasciitis\u2010like features including bland spindle cells with evenly distributed chromatin, admixed inflammatory cells (mainly lymphocytes) and often a myxoid stroma. Immunohistochemistry showed positivity for smooth muscle actin in 14\/20 cases, keratin in 8\/19, desmin in 7\/20 and anaplastic lymphoma kinase (ALK) in 10\/21 cases. Fluorescent <jats:italic>in situ<\/jats:italic> hybridization was performed in six ALK+ cases; all were negative for <jats:italic>ALK<\/jats:italic> gene rearrangement.<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold> :\u2002Pseudosarcomatous myofibroblastic proliferations of the genitourinary tract may show ALK immunopositivity but do not show consistent <jats:italic>ALK<\/jats:italic> rearrangement. Given subtle morphological differences and more consistently benign behaviour, their relationship to inflammatory myofibroblastic tumour at other sites remains uncertain.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2006.02376.x","type":"journal-article","created":{"date-parts":[[2006,3,28]],"date-time":"2006-03-28T13:17:54Z","timestamp":1143551874000},"page":"569-578","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["ALK expression in pseudosarcomatous myofibroblastic proliferations of the genitourinary tract"],"prefix":"10.1111","volume":"48","author":[{"given":"M S","family":"Hirsch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P Dal","family":"Cin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C D M","family":"Fletcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,3,28]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"364","article-title":"Inflammatory myofibroblastic tumor: cytogenetic evidence supporting clonal origin","volume":"11","author":"Su LD","year":"1998","journal-title":"Mod. 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