{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T13:52:45Z","timestamp":1785678765435,"version":"3.56.0"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,5,23]],"date-time":"2006-05-23T00:00:00Z","timestamp":1148342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:p><jats:bold>Aims<\/jats:bold> :\u2002The histological diagnosis is critical for the postsurgical management and follow\u2010up of thyroid malignancies. The differential diagnosis between papillary carcinoma and hyperfunctioning lesions, either with papillary hyperplasia or with a follicular architecture, can create real diagnostic difficulty. The aim of this study was to evaluate the expression of several antibodies considered to be markers of malignancy in malignant and hyperfunctioning thyroid neoplasms and to include the most effective of them in a diagnostic panel.<\/jats:p><jats:p><jats:bold>Methods and results<\/jats:bold> :\u2002One hundred resected thyroid nodules\u201458 hyperfunctioning benign lesions and 42 papillary carcinomas (14 follicular variant, 14 macrofollicular variant and 14 classic type)\u2014were immunohistochemically studied for HBME\u20101, galectin\u20103, cytokeratin (CK) 19 and RET\u2010proto\u2010oncogene. HBME\u20101 and galectin\u20103 showed 92.8% and 89% sensitivity, respectively, and their coexpression was present in 36 out of 42 papillary carcinomas (85.7%) and absent in non\u2010malignant lesions. Their association increased sensitivity to 94.7% and the diagnostic accuracy to 97.9% and involved the highest number of cases (95%) in comparison with two other panels including, respectively, three (HBME\u20101, galectin\u20103, CK19) and all four antibodies.<\/jats:p><jats:p><jats:bold>Conclusion<\/jats:bold> :\u2002An immunohistochemical panel consisting of HBME\u20101 and galectin\u20103 can make a correct distinction between malignant and hyperfunctioning thyroid neoplasms with high diagnostic accuracy.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2006.02428.x","type":"journal-article","created":{"date-parts":[[2006,5,23]],"date-time":"2006-05-23T10:24:51Z","timestamp":1148379891000},"page":"795-800","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Simultaneous immunohistochemical expression of HBME\u20101 and galectin\u20103 differentiates papillary carcinomas from hyperfunctioning lesions of the thyroid"],"prefix":"10.1111","volume":"48","author":[{"given":"E D","family":"Rossi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Raffaelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Mule'","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Miraglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C P","family":"Lombardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F M","family":"Vecchio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Fadda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,5,23]]},"reference":[{"key":"e_1_2_7_2_2","volume-title":"Surgical pathology of the thyroid. 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