{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:16:26Z","timestamp":1789776986032,"version":"4.0.1"},"reference-count":14,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,5,23]],"date-time":"2006-05-23T00:00:00Z","timestamp":1148342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:p><jats:bold>Aims<\/jats:bold> :\u2002Undifferentiated nasopharyngeal non\u2010keratinizing carcinoma (UNPC), formerly known as lymphoepithelioma, frequently metastasizes at an early stage to regional lymph nodes and, thus, may be difficult to distinguish from Hodgkin's lymphoma (HL) or anaplastic large cell lymphoma (ALCL). CD30 expression is a useful diagnostic stain in both HL and ALCL, but its expression in UNPC deserves clarification. The aim of this study was to evaluate CD30 expression in UNPC and lymphoepithelioma\u2010like carcinoma (LELC) from other anatomic locations and compare it with ALCL and squamous cell carcinoma (SCC).<\/jats:p><jats:p><jats:bold>Methods and results<\/jats:bold> :\u2002CD30 immunoreactivity was examined in 38 cases of primary or metastatic UNPC, six cases of LELC, 10 cases of SCC and seven cases of ALCL. CD30 immunoreactivity was observed in four of 38 (10.5%) cases of UNPC. CD30 staining was absent in all cases of LELC (0\/6) and SCC (0\/10). All cases of ALCL (7\/7) were strongly positive for CD30.<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold> :\u2002The majority of cases of UNPC are immunohistochemically negative for CD30; however, a small subset of cases expresses CD30 antigen. These findings provide additional evidence that CD30 expression is not restricted to neoplasms of lymphoid origin. This should be taken into consideration when interpreting CD30 immunohistology and the possibility of UNPC.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2006.02449.x","type":"journal-article","created":{"date-parts":[[2006,5,23]],"date-time":"2006-05-23T10:24:51Z","timestamp":1148379891000},"page":"855-861","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Expression of CD30 (Ber\u2010H2) in nasopharyngeal carcinoma, undifferentiated type and lymphoepithelioma\u2010like carcinoma. A comparison study with anaplastic large cell lymphoma"],"prefix":"10.1111","volume":"48","author":[{"given":"J R","family":"Kneile","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Suster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"P E","family":"Wakely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,5,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19821001)50:7<1344::AID-CNCR2820500721>3.0.CO;2-O"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2004.02007.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90361-S"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/299065a0"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V66.4.848.848"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V74.5.1678.1678"},{"key":"e_1_2_6_8_2","first-page":"446","article-title":"Ki\u20101 (CD30) antigen is regularly expressed by tumor cells of embryonal carcinoma","volume":"133","author":"Pallesen G","year":"1988","journal-title":"Am. 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Pathology and genetics of head and neck tumours.","author":"Barnes L","year":"2005"},{"key":"e_1_2_6_14_2","first-page":"1413","article-title":"Cytokeratin expression and vimentin content in large cell anaplastic lymphomas and other non\u2010Hodgkin's lymphomas","volume":"138","author":"Gustmann C","year":"1991","journal-title":"Am. J. Pathol."},{"key":"e_1_2_6_15_2","first-page":"317","article-title":"Cytokeratin in anaplastic large cell lymphoma","volume":"7","author":"Frierson HF","year":"1994","journal-title":"Mod. Pathol."}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2559.2006.02449.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2559.2006.02449.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T16:13:57Z","timestamp":1697213637000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2559.2006.02449.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5,23]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["10.1111\/j.1365-2559.2006.02449.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2559.2006.02449.x","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5,23]]},"assertion":[{"value":"2006-05-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}