{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T19:29:24Z","timestamp":1791833364860,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,6,30]],"date-time":"2006-06-30T00:00:00Z","timestamp":1151625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:p><jats:bold>Aims:\u2002<\/jats:bold> Low\u2010grade fibrosarcomas are tumours that mainly affect the extremities and trunk of adults of either sex. Among these, low\u2010grade fibromyxoid sarcoma (FMS), hyalinizing spindle cell tumour with giant collagen rosettes (HST) and sclerosing epithelioid fibrosarcoma (SEF) are well\u2010established entities. In this study, our aim was to describe a group of low\u2010grade fibrosarcomatous tumours, which could not be encompassed by these entities. These low\u2010grade fibrosarcomas, not otherwise specified (FNOS) were provisionally designated as \u2018fibrosarcoma, low\u2010grade fibroblastic type\u2019.<\/jats:p><jats:p><jats:bold>Methods and results:\u2002<\/jats:bold> In the soft tissue tumour registry we found 39 FNOS (46%), 31 FMS (36%), 11 SEF (13%) and four HST (5%). FNOS occurred in older patients than FMS (mean age 56.3\u2003years versus 33.7\u2003years). They mainly showed fibrous features, but myxoid areas could also be seen. While cells tended to be loosely arranged in the myxoid areas, densely packed sheets with a storiform pattern, fascicular arrangements or regions without a defined growth pattern were observed in the fibrous areas. However, neither whirling nor swirling patterns were found. Arcade\u2010like vessels were not visible; pseudolipoblasts did not occur. FNOS exhibited increased atypia and mitotic count compared with the other sarcomas studied [FNOS, mean value 4.6 mitoses\/10 high\u2010power field (HPF); FMS, 0.7\/10\u2003HPF). Follow\u2010up data were available in 21 FNOS patients. In seven cases (33.3%), local recurrences were reported. Three patients (14.3%) developed metastases and all of them died of tumour.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> The term \u2018fibrosarcoma, low\u2010grade fibroblastic type\u2019 should be used as a diagnosis of exclusion. Further studies should elucidate whether it represents a distinct fibrosarcoma type.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2006.02480.x","type":"journal-article","created":{"date-parts":[[2006,6,30]],"date-time":"2006-06-30T16:11:24Z","timestamp":1151683884000},"page":"152-160","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Low\u2010grade fibrosarcoma\u2014report on 39 not otherwise specified cases and comparison with defined low\u2010grade fibrosarcoma types"],"prefix":"10.1111","volume":"49","author":[{"given":"T","family":"Hansen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Katenkamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Brodhun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Katenkamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_7_2_2","volume-title":"World Health Organization classification of tumours. Tumours of soft tissue and bone.","author":"Fletcher CDM","year":"2002"},{"key":"e_1_2_7_3_2","volume-title":"Enzinger and Weiss's soft tissue tumors","author":"Weiss SW","year":"2001"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199604000-00001"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200106000-00001"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/019131290882259"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199911000-00015"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200010000-00004"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199712000-00011"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200309000-00006"},{"key":"e_1_2_7_11_2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00292-002-0569-6","article-title":"Sclerosing epithelioid fibrosarcoma","volume":"24","author":"Hindermann W","year":"2003","journal-title":"Pathologe"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00292-004-0739-9"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1078\/0065-1281-00649"},{"key":"e_1_2_7_14_2","volume-title":"Diagnostic soft tissue pathology.","author":"Miettinen M","year":"2003"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/019131290882187"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199306000-00007"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2004.01886.x"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000146014.22624.8e"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199509000-00001"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1998.00530.x"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980601)82:11<2081::AID-CNCR1>3.0.CO;2-Z"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000157938.95785.da"},{"key":"e_1_2_7_23_2","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1097\/00000478-199810000-00008","article-title":"Low\u2010grade myofibroblastic sarcoma. Analysis of 18 cases in the spectrum of myofibroblastic tumors","volume":"22","author":"Mentzel T","year":"1998","journal-title":"Am. J. Surg. 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