{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:06:46Z","timestamp":1791104806253,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,8,18]],"date-time":"2006-08-18T00:00:00Z","timestamp":1155859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p><jats:bold>Aims:\u2002<\/jats:bold> Follicular lymphoma (FL) arising primarily in the skin has recently been proposed as a distinct entity on the basis of a low incidence of t(14;18)(q32;q21) and bcl\u20102 expression, with a very high percentage of patients surviving more than 5\u2003years. However, cases of t(14;18)(q32;q21)\u2010positive primary cutaneous FL (PCFL) and examples of t(14;18)(q32;q21)\u2010negative FL at nodal and other extranodal sites, are well documented. The aim of this study was to test the hypothesis that there is a subtype of FL lacking t(14;18)(q32;q21), which preferentially involves certain sites but is not restricted by anatomical location.<\/jats:p><jats:p><jats:bold>Methods and results:\u2002<\/jats:bold> A cohort of 47 stage 1 FL was stratified according to the presence or absence of t(14;18)(q32;q21) using conventional cytogenetics, polymerase chain reaction and interphase fluorescence <jats:italic>in situ<\/jats:italic> hybridization. Compared with t(14;18)(q32;q21)\u2010positive cases, FL lacking the translocation were less likely to express CD10 or bcl\u20102 (<jats:italic>P\u2003&lt;<\/jats:italic>\u20030.01), made up a significantly greater proportion of cases arising at extranodal sites (<jats:italic>P\u2003&lt;<\/jats:italic>\u20030.001) and had a significantly better overall and disease\u2010specific 5\u2010year survival (<jats:italic>P\u2003&lt;<\/jats:italic>\u20030.01).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> These results support the concept of a subtype of FL lacking t(14;18)(q32;q21), characterized by low\u2010intensity bcl\u20102 expression, a predilection for extranodal sites, particularly the skin, and a more favourable outcome than t(14;18)(q32;q21)\u2010positive FL.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2006.02501.x","type":"journal-article","created":{"date-parts":[[2006,8,18]],"date-time":"2006-08-18T09:33:23Z","timestamp":1155893603000},"page":"229-241","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["<i>BCL2<\/i> gene abnormalities define distinct clinical subsets of follicular lymphoma"],"prefix":"10.1111","volume":"49","author":[{"given":"J R","family":"Goodlad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P J","family":"Batstone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D A","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N M","family":"Kernohan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D A","family":"Levison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J M","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8,18]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-07-2009"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/028418600430707"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2003.12.007"},{"key":"e_1_2_7_5_2","first-page":"131","volume-title":"Extranodal lymphomas.","author":"Isaacson PG","year":"1994"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1994.tb08560.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"crossref","first-page":"3922","DOI":"10.1182\/blood.V95.12.3922","article-title":"Primary cutaneous follicle center cell lymphoma with follicular growth patern","volume":"95","author":"Cerroni L","year":"2002","journal-title":"Blood"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04128.x"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200107000-00005"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200206000-00006"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200202000-00011"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200005000-00007"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63802-3"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdg168"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200202000-00008"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.10.3806"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V101.3.1149"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04086.x"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/106689690100900405"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.55.9.684"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2004.01804.x"},{"key":"e_1_2_7_22_2","first-page":"432","article-title":"Clinicopathologic, immunophenotypic, and molecular characterization of primary cutaneous follicular B\u2010cell lymphoma","volume":"137","author":"Bergman R","year":"2001","journal-title":"Arch. Dermatol."},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1309\/2TJU-DNLQ-5JBA-AB4T"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.3.647"},{"key":"e_1_2_7_25_2","first-page":"162","volume-title":"World Health Organization classification of tumours: pathology and genetics. Tumours of the haematopoetic and lymphoid tissues.","author":"Nathwani BN","year":"2001"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2004.018135"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428190109097729"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2002.01360.x"},{"key":"e_1_2_7_29_2","first-page":"168","volume-title":"World Health Organization classification of tumours: pathology and genetics. Tumours of the haematopoetic and lymphoid tissues.","author":"Swerdlow SH","year":"2001"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1995.tb08938.x"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200106000-00004"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.55.9.648"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199807)185:3<229::AID-PATH86>3.0.CO;2-L"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700051"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2559.2006.02501.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2559.2006.02501.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T17:29:14Z","timestamp":1697218154000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2559.2006.02501.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,18]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1111\/j.1365-2559.2006.02501.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2559.2006.02501.x","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,18]]},"assertion":[{"value":"2006-08-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}