{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T01:32:00Z","timestamp":1721525520569},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,8,10]],"date-time":"2006-08-10T00:00:00Z","timestamp":1155168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p><jats:bold>Aims<\/jats:bold> To investigate by immunohistochemical analysis the expression of the TCL1 oncogene product and of CD27 in 25 cases of primary cutaneous B\u2010cell lymphomas (PCBCL) classified according to the World Health Organization\u2013European Organization for Research and Treatment of Cancer classification of cutaneous lymphomas. In B\u2010cell ontogenesis TCL1 is mainly expressed by \u2018naive\u2019 B lymphocytes and by a subset of germinal centre B cells, whereas CD27 is expressed by a subset of germinal centre B cells, \u2018memory\u2019 B lymphocytes and plasma cells, suggesting that their expression in physiological conditions is mutually exclusive.<\/jats:p><jats:p><jats:bold>Methods and results<\/jats:bold> Overall, TCL1 was expressed in 5\/25 cases (20%) and CD27 in 15\/25 cases (60%). Furthermore, 7\/25 cases (28%) were TCL1\u2013 and CD27\u2013 and 2\/25 cases (8%) were TCL1+ and CD27+. In particular, primary cutaneous follicle\u2010centre lymphomas (10 cases) showed a variable expression of both TCL1 and CD27, whereas primary cutaneous marginal\u2010zone B\u2010cell lymphomas (eight cases) showed, with the exception of a single case, a definite CD27+\/TCL1\u2013 profile.<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold> These findings indicate: (i) the TCL1 oncogene product is uncommonly expressed in PCBCL (20% of cases, mainly of the follicle\u2010centre subtype); (ii) in contrast, CD27 is often expressed in PCBCL (60% of cases), mainly of the marginal\u2010zone subtype; (iii) the coexpression of TCL1 and CD27 may be seldom observed in PCBCL (8% of cases); (iv) PCBCL does not seem to show, in terms of either TCL1 or CD27 expression, significant differences compared with its systemic counterparts.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2006.02506.x","type":"journal-article","created":{"date-parts":[[2006,8,10]],"date-time":"2006-08-10T13:50:23Z","timestamp":1155217823000},"page":"343-348","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Expression of TCL1 and CD27 in primary cutaneous B\u2010cell lymphomas"],"prefix":"10.1111","volume":"49","author":[{"given":"E","family":"Pescarmona","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Remotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Perez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Monaco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Pacchiarotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Faraggiana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Russo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C D","family":"Baroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9,15]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3502"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.26.12530"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.6.2949"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780264"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/80877"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2005.04.004"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(00)01605-4"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.7.4034"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403202"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.7.3028"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)00039-3"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.17.9809"},{"key":"e_1_2_7_14_2","first-page":"2095","article-title":"Regulation of TCL1 expression in B\u2010 and T\u2010cell lymphomas and reactive lymphoid tissues","volume":"60","author":"Narducci MG","year":"2000","journal-title":"Cancer Res."},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4800(03)00007-8"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.12.7432"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/1042819021000006385"},{"key":"e_1_2_7_18_2","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1001\/archderm.1993.01680240093016","article-title":"Skin\u2010associated lymphoid tissue (SALT)\u2010related B\u2010cell lymphomas (primary cutaneous B\u2010cell lymphomas). A concept and a clinicopathologic entity","volume":"129","author":"Giannotti B","year":"1993","journal-title":"Arch. Dermatol."},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1994.tb08560.x"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1085-5629(00)80009-7"},{"key":"e_1_2_7_21_2","unstructured":"PescarmonaE PerezM RemottiDet\u00a0al.Expression of TCL1 and CD27 and analysis of IgVH mutations in primary cutaneous B\u2010cell lymphomas.XII Meeting of the European Association for Haematopathology Thessaloniki (Greece).26 September to 1 October 2004."}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2559.2006.02506.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2559.2006.02506.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T11:49:50Z","timestamp":1697370590000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2559.2006.02506.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,15]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["10.1111\/j.1365-2559.2006.02506.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2559.2006.02506.x","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9,15]]},"assertion":[{"value":"2006-09-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}