{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T05:50:06Z","timestamp":1782625806077,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,9,15]],"date-time":"2006-09-15T00:00:00Z","timestamp":1158278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p><jats:bold>Aims:\u2002<\/jats:bold> To describe the pathology of central nervous system (CNS) fungal infections with particular reference to India.<\/jats:p><jats:p><jats:bold>Methods and results:\u2002<\/jats:bold> This was a retrospective study from 1988 to 2004 constituting 130 cases. The diagnosis was based on morphology of biopsy\/autopsy material. These included aspergillosis (<jats:italic>n<\/jats:italic>\u2003=\u200373), zygomycosis (<jats:italic>n<\/jats:italic>\u2003=\u200340), cryptococcosis (<jats:italic>n<\/jats:italic>\u2003=\u20032), rhodotorulosis (<jats:italic>n<\/jats:italic>\u2003=\u20031), candidiasis (<jats:italic>n<\/jats:italic>\u2003=\u20035), maduramycosis (<jats:italic>n<\/jats:italic>\u2003=\u20031), pheohyphomycosis (<jats:italic>n<\/jats:italic>\u2003=\u20033) and mixed infections (<jats:italic>n<\/jats:italic>\u2003=\u20035). Predisposing risk factors were present in 49 (38%) patients only. The majority of the patients were immunocompetent. The commonest risk factor was diabetes mellitus, the commonest route of infection was from a contiguous site and the commonest pathology was granuloma. Culture positivity was seen in only 31%.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Environmental factors in tropical countries such as India play a significant role in the pathogenesis of CNS fungal infections.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2006.02515.x","type":"journal-article","created":{"date-parts":[[2006,9,15]],"date-time":"2006-09-15T08:57:32Z","timestamp":1158310652000},"page":"396-405","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Pathology of fungal infections of the central nervous system: 17\u2003years' experience from Southern India"],"prefix":"10.1111","volume":"49","author":[{"given":"C","family":"Sundaram","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Umabala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Laxmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A K","family":"Purohit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V S S V","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Panigrahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B P","family":"Sahu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M V","family":"Sarathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Kaul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Borghain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A K","family":"Meena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S S","family":"Jayalakshmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Suvarna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Mohandas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J M K","family":"Murthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,9,15]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"147","volume-title":"Progress in Clinical Neuroscience","author":"Chandramuki A","year":"1989"},{"key":"e_1_2_7_3_2","first-page":"239","article-title":"Cerebral aspergillosis\u2014distinct clinicopathologic pattern in 62 cases","volume":"37","author":"Kak VK","year":"1989","journal-title":"Neurol. 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