{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T08:57:05Z","timestamp":1784883425164,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,10,6]],"date-time":"2006-10-06T00:00:00Z","timestamp":1160092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:p><jats:bold>Aims<\/jats:bold> To define a new histological staging and grading system for primary biliary cirrhosis (PBC), to provide more information reflecting clinical laboratory data and the prognosis to hepatologists.<\/jats:p><jats:p><jats:bold>Methods and results<\/jats:bold> First, 17 histological lesions of PBC were scored in 188 needle liver biopsy specimens. Factor analysis yielded three independent groups of factors: factor 1 (fibrosis, fibrous piecemeal necrosis, orcein\u2010positive granules, bile plugs, Mallory bodies, feathery degeneration, bile duct loss and atypical ductular proliferation); factor 2 (portal inflammation, eosinophilic infiltration, lymphoid follicles, epithelioid granulomas, interface hepatitis and chronic cholangitis); and factor 3 (interface hepatitis, lobular hepatitis, acidophilic bodies and pigmented macrophages). The eight findings of factor 1, but not factors 2 and 3, were significantly correlated with clinical laboratory data and scores in the Mayo Clinic's prognostic model. Factor 1 lesions may reflect histological progression (staging), while factor 2 and 3 lesions may relate to necroinflammatory activity (grading). Then, we devised a staging and grading system using three lesions (bile duct loss, fibrosis and orcein\u2010positive granules) from factor 1 and three from factors 2 and 3 (chronic cholangitis, interface hepatitis and lobular hepatitis).<\/jats:p><jats:p><jats:bold>Conclusion<\/jats:bold> This new system might provide more pathological information on PBC patients for hepatologists.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2006.02537.x","type":"journal-article","created":{"date-parts":[[2006,10,6]],"date-time":"2006-10-06T13:26:53Z","timestamp":1160141213000},"page":"466-478","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Proposal of a new staging and grading system of the liver for primary biliary cirrhosis"],"prefix":"10.1111","volume":"49","author":[{"given":"K","family":"Hiramatsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Aoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Zen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Aishima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Kitagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Nakanuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,10,26]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.36373"},{"key":"e_1_2_5_3_2","first-page":"239","volume-title":"Diseases of the liver and biliary system","author":"Sherlock S","year":"1997"},{"key":"e_1_2_5_4_2","first-page":"435","volume-title":"Pathology of the liver","author":"Portmann BC","year":"2001"},{"key":"e_1_2_5_5_2","first-page":"66","volume-title":"Liver biopsy interpretation","author":"Scheuer PJ","year":"1994"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(79)90396-2"},{"key":"e_1_2_5_7_2","first-page":"506","article-title":"Correlation between disappearance of the intrahepatic bile ducts and histologic changes in the liver in primary biliary cirrhosis","volume":"76","author":"Nakanuma Y","year":"1981","journal-title":"Am. 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