{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:23:14Z","timestamp":1762100594103},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,11,27]],"date-time":"2006-11-27T00:00:00Z","timestamp":1164585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p><jats:bold>Aims:\u2002<\/jats:bold> To elucidate the expression and regulation of survivin in normal tissues.<\/jats:p><jats:p><jats:bold>Methods and results:\u2002<\/jats:bold> A novel monoclonal antibody (12C4) to survivin was generated. Application of this antibody to determine survivin expression in human normal adult tissues revealed that most adult tissues do not express survivin and, where it is present, survivin is largely restricted to a small subset of epithelial cells and cells with proliferative potential such as thymus. Survivin expression among positive tissues showed individual variations, ranging from zero to &lt;\u200a5% positive cells in epithelial cell populations. Testis is the only human adult tissue highly expressing survivin, with 60\u201370% positivity in the nuclei of spermatogonia. Consistent with deregulated expression of survivin associated with oncogenesis, we found that certain ligands and transcription factors differentially modulate survivin promoter activity in cancer cells versus normal\/untransformed cells.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Deregulation of survivin transcription controls in individual epithelial cells may contribute to oncogenesis in various human adult tissues.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2006.02556.x","type":"journal-article","created":{"date-parts":[[2006,11,27]],"date-time":"2006-11-27T20:12:07Z","timestamp":1164658327000},"page":"622-633","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Characterization of the 12C4 survivin monoclonal antibody and insight into the expression of survivin in human adult tissues"],"prefix":"10.1111","volume":"49","author":[{"given":"B","family":"Spaulding","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Ghadersohi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Gellert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X","family":"Ling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Black","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,11,27]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/25141"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/70242"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207113"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20140"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0897-917"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/6.6.529"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.7.2091"},{"key":"e_1_2_7_9_2","first-page":"8664","article-title":"Evidence that APC regulates survivin expression: a possible mechanism contributing to the stem cell origin of colon cancer","volume":"61","author":"Zhang T","year":"2001","journal-title":"Cancer Res."},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20031588"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20032092"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20032033"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0500303102"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.10327"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602340"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(81)73054-4"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00776.x"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2005.03.037"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1042\/0264-6021:3440305"},{"key":"e_1_2_7_20_2","first-page":"1701","article-title":"A family of AP\u20102 proteins regulates c\u2010erbB\u20102 expression in mammary carcinoma","volume":"13","author":"Bosher JM","year":"1996","journal-title":"Oncogene"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20768"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208330"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M106643200"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205353"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.037192"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.4.1457"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2004.05.023"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.50.4.542"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-200303000-00012"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302280"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2559.2006.02556.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2559.2006.02556.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T18:01:10Z","timestamp":1697220070000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2559.2006.02556.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,27]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1111\/j.1365-2559.2006.02556.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2559.2006.02556.x","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,27]]},"assertion":[{"value":"2006-11-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}