{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:37:41Z","timestamp":1790314661726,"version":"4.1.0"},"reference-count":88,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,12,14]],"date-time":"2006-12-14T00:00:00Z","timestamp":1166054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p>Barrett's oesophagus, a precancerous condition for oesophageal adenocarcinoma, detected on endoscopy and confirmed on histology, shows intestinal metaplasia of the lower oesophagus. The significance of microscopic foci of intestinal metaplasia at the gastro\u2013oesophageal junction, corresponding either to so\u2010called \u2018ultrashort\u2019 segment Barrett's oesophagus, or to carditis with intestinal metaplasia, is still a matter of debate. The surveillance of patients with Barrett's oesophagus is still based on systematic biopsy sampling of Barrett's mucosa on endoscopy, looking for dysplasia. Although well\u2010established classifications of dysplasia are now used by most pathologists, there remain numerous problems with this subjective marker (sampling, diagnostic reproducibility, natural history, etc). Therefore, many alternative biomarkers have been proposed, but only DNA aneuploidy, proliferation markers and p53 loss of heterozygosity\/overexpression have been shown to be of some use at the present time. Some endoscopic improvements already allow a better selection of biopsies, and it may be that in future new technologies will allow \u2018virtual biopsies\u2019. On the other hand, the role of pathologists now extends to the evaluation of new therapeutic modalities of early neoplastic lesions in Barrett's oesophagus, especially endoscopic mucosal resection.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2006.02569.x","type":"journal-article","created":{"date-parts":[[2006,12,15]],"date-time":"2006-12-15T01:14:10Z","timestamp":1166145250000},"page":"3-14","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Barrett's oesophagus\u2014a pathologist's view"],"prefix":"10.1111","volume":"50","author":[{"given":"J\u2010F","family":"Fl\u00e9jou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Svrcek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,12,14]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.agast960614"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05910.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.083600"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(92)90121-I"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.08.053"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(05)70167-4"},{"key":"e_1_2_7_8_2","first-page":"1","article-title":"Tissue and cell imaging in situ: potential for applications in pathology and endoscopy","volume":"52","author":"Scoazec J\u2010Y.","year":"2003","journal-title":"Gut"},{"key":"e_1_2_7_9_2","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1111\/j.1572-0241.1998.00324.x","article-title":"Short segment Barrett's esophagus\u2014the need for standardization of the definition and endoscopic criteria","volume":"93","author":"Sharma P","year":"1998","journal-title":"Am. 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