{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T15:27:51Z","timestamp":1763479671462},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,1,3]],"date-time":"2007-01-03T00:00:00Z","timestamp":1167782400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p><jats:bold>Aims:\u2002<\/jats:bold> To analyse the possible activation of distinct molecular pathways in mucosa\u2010associated lymphoid tissue (MALT) lymphoma, we determined the prevalence of trisomies 3, 12, 18 in MALT lymphomas from different organs, as well as the prevalence of translocations of the <jats:italic>MALT1<\/jats:italic> gene in a subset of primary breast MALT lymphomas. We compared the numerical cytogenetic alterations in lymphomas, precursor lesions and in normal non\u2010haematolymphoid tissue from the same organs.<\/jats:p><jats:p><jats:bold>Methods and results:\u2002<\/jats:bold> Forty\u2010two samples of paraffin\u2010embedded tissue (29 MALT lymphomas from stomach, breast, parotid and thyroid; two Sj\u00f6gren's syndrome; two Hashimoto's thyroiditis and nine reactive samples) were studied by fluorescence <jats:italic>in situ<\/jats:italic> hybridization (FISH). Analysed together, the cases of gastric, parotid and thyroid MALT lymphomas presented trisomy 3 in 46%, trisomy 12 in 28% and trisomy 18 in 21% of the cases. In contrast to other locations, trisomy 3 was not present in the majority of the cases of primary breast MALT lymphomas. None of the nine breast cases presented <jats:italic>MALT1<\/jats:italic> gene rearrangements. Half of the cases of preneoplastic lesions exhibited trisomy 3 and trisomy 12; none exhibited trisomy 18.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Trisomy 3 is the most frequent numerical abnormality in gastric, parotid and thyroid but not in primary breast MALT lymphomas. <jats:italic>MALT1<\/jats:italic> gene rearrangements are also rare in this location, suggesting that distinct molecular pathways may be activated in breast cases.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2007.02580.x","type":"journal-article","created":{"date-parts":[[2007,1,4]],"date-time":"2007-01-04T06:37:35Z","timestamp":1167892655000},"page":"217-224","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Cytogenetic abnormalities in MALT lymphomas and their precursor lesions from different organs. A fluorescence <i>in situ<\/i> hybridization (FISH) study"],"prefix":"10.1111","volume":"50","author":[{"given":"C","family":"Jo\u00e3o","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Farinha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M G","family":"Da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Crespo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Cabe\u00e7adas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,3]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.11.3909"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19831015)52:8<1410::AID-CNCR2820520813>3.0.CO;2-3"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008396618983"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031887"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200401000-00012"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200305000-00017"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(88)80259-4"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198503073121001"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199602)178:2<122::AID-PATH486>3.0.CO;2-D"},{"key":"e_1_2_7_11_2","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1182\/blood.V87.1.299.299","article-title":"Marginal zone B\u2010cell lymphomas of different sites share similar cytogenetic and morphologic features","volume":"87","author":"Dierlamm J","year":"1996","journal-title":"Blood"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.011"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V85.8.2000.bloodjournal8582000"},{"key":"e_1_2_7_14_2","first-page":"995","article-title":"Numerical cytogenetics abnormalities of chromosomes 3, 7, and 12 in marginal zone B\u2010cell lymphomas","volume":"9","author":"Brynes RK","year":"1996","journal-title":"Mod. Pathol."},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008202303666"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65499-5"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/8767"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80957-5"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-09-2963"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-10-3236"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403644"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.1150"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64157-0"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M009984200"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1080\/10428190310001623793"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-06-2297"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04630.x"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.990160202"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01464339"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-11-3502"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403501"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1715"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.25305"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.33047"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.1.3"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1409"},{"key":"e_1_2_7_37_2","doi-asserted-by":"crossref","first-page":"625","DOI":"10.3748\/wjg.v12.i4.625","article-title":"Genetic alterations in benign lesions: chronic gastritis and gastric ulcer","volume":"12","author":"Gobbo Cesar AC","year":"2006","journal-title":"World J. Gastroenterol."},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1097\/00022744-200206000-00004"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2559.2007.02580.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2559.2007.02580.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T00:37:52Z","timestamp":1697243872000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2559.2007.02580.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1111\/j.1365-2559.2007.02580.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2559.2007.02580.x","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1]]},"assertion":[{"value":"2007-01-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}