{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T18:47:20Z","timestamp":1773773240002,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,4,27]],"date-time":"2007-04-27T00:00:00Z","timestamp":1177632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:p><jats:bold><jats:italic>Aims<\/jats:italic>:\u2002<\/jats:bold> The Revised European American Lymphoma classification uses the term Hodgkin's\u2010like anaplastic large cell lymphoma (HD\u2010like ALCL) for borderline cases with features of both anaplastic large cell lymphoma (ALCL) and classical Hodgkin's lymphoma (HL). The aim of this study was to clarify the association between cytotoxic molecule (CM) expression and clinical outcome in HD\u2010like ALCL.<\/jats:p><jats:p><jats:bold><jats:italic>Methods and results<\/jats:italic>:\u2002<\/jats:bold> Subjects were 59 patients with HD\u2010like ALCL, defined by nodal presentation without mediastinal bulky lesions, T\u2010 or null\u2010cell phenotype, CD30+ anaplastic lymphoma kinase (ALK)\u2013 phenotype and by confluent sheets or nodules of large cells mimicking classic Hodgkin and Reed\u2013Sternberg cells. We evaluated the presenting features and prognosis of subjects on categorization into two defined groups, namely CM (TIA1 and\/or granzyme B)\u2010positive (<jats:italic>n<\/jats:italic>\u2003= 21) and CM\u2010negative (<jats:italic>n<\/jats:italic>\u2003=\u200338). The series consisted of 18 women and 41 men ranging from 16 to 88\u2003years of age (median 59\u2003years). The CM+ group had poorer disease\u2010specific survival than the CM\u2013 group (<jats:italic>P\u2003=<\/jats:italic> 0.02) despite the absence of differences in other clinical characteristics. Multivariate analysis confirmed that CM expression was an independent prognostic factor, in contrast to phenotypic categorization (T\u2010cell vs. null\u2010cell group), which had no prognostic impact on disease\u2010specific survival.<\/jats:p><jats:p><jats:bold><jats:italic>Conclusion<\/jats:italic>:\u2002<\/jats:bold> CM expression is predictive of prognosis in HD\u2010like ALCL.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2007.02674.x","type":"journal-article","created":{"date-parts":[[2007,5,7]],"date-time":"2007-05-07T01:34:46Z","timestamp":1178501686000},"page":"705-715","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cytotoxic molecule expression is predictive of prognosis in Hodgkin's\u2010like anaplastic large cell lymphoma"],"prefix":"10.1111","volume":"50","author":[{"given":"N","family":"Asano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Kagami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u2010I","family":"Tamaru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u2010S","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Shimoyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Yoshino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Morishima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,4,27]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.5.1361.1361"},{"issue":"2","key":"e_1_2_7_3_2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/annonc\/8.suppl_2.S17","article-title":"Classification of T\u2010cell and NK\u2010cell neoplasms based on the REAL classification","volume":"8","author":"Jaffe ES","year":"1997","journal-title":"Ann. 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