{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:36:20Z","timestamp":1791052580532,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,6,25]],"date-time":"2007-06-25T00:00:00Z","timestamp":1182729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:p><jats:bold>Aims:\u2002<\/jats:bold> To compare two different multiparameter histopathological scoring indices and determine their prognostic value in patients presenting with adrenocortical carcinoma (ACC).<\/jats:p><jats:p><jats:bold>Methods and results:\u2002<\/jats:bold> Seventy\u2010nine adrenal cortical tumours were divided into adenomas (<jats:italic>n<\/jats:italic>\u2003=\u200317), non\u2010metastatic carcinomas (<jats:italic>n<\/jats:italic>\u2003=\u200324) and carcinomas with metastatic disease and\/or local recurrence during follow\u2010up (<jats:italic>n<\/jats:italic>\u2003=\u200319) or at time of presentation (<jats:italic>n<\/jats:italic>\u2003= 19). All cases were scored according to the Weiss revisited index (WRI) and the Van Slooten index (VSI). Both scoring indices yielded a significantly different score (<jats:italic>P\u2003&lt;<\/jats:italic>\u20030.005) between adenomas and carcinomas. Non\u2010metastasized carcinomas had a lower score with both indices compared with carcinomas with metastases at the time of presentation (VSI, <jats:italic>P<\/jats:italic>\u2003=\u20030.017; WRI, <jats:italic>P<\/jats:italic>\u2003=\u20030.019). The VSI also distinguished ACC that had metastasized at any time from those that had not (<jats:italic>P\u2003=<\/jats:italic>\u20030.015). Cancer\u2010specific survival in patients with metastasized ACC correlated with the scores for both indices (VSI, <jats:italic>P<\/jats:italic>\u2003=\u20030.0078; WRI, <jats:italic>P<\/jats:italic>\u2003=\u20030.0025). Time from diagnosis of ACC to development of metastatic disease was correlated with the WRI (<jats:italic>P\u2003=<\/jats:italic>\u20030.036, <jats:italic>r<\/jats:italic>\u2003=\u2003\u22120.350).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> The VSI and the WRI have equal validity in the correct categorization of ACC and adenomas. 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