{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:30:00Z","timestamp":1791268200394,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,6,30]],"date-time":"2007-06-30T00:00:00Z","timestamp":1183161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:p><jats:bold>Aims:\u2002<\/jats:bold> The human G\u2010CSF\u2010stimulated clone\u20101 (<jats:italic>hGC\u20101<\/jats:italic>) gene encodes a 510\u2010amino acid olfactomedin\u2010related glycoprotein whose exact <jats:italic>in vivo<\/jats:italic> localization and function still remain elusive. The aim of this study was to demonstrate hGC\u20101 protein localization in the normal human gastrointestinal tract and to explore further a potential relationship between hGC\u20101 expression and gastric carcinoma.<\/jats:p><jats:p><jats:bold>Methods and results:\u2002<\/jats:bold> A specific hGC\u20101 polyclonal antibody raised against purified hGC\u20101 protein was developed and characterized. Using immunohistochemistry, it was demonstrated that hGC\u20101 is expressed in the oesophagus, stomach, small intestine and colon. The expression pattern of hGC\u20101 protein in 173 cases of gastric carcinoma was investigated and a striking correlation was demonstrated between hGC\u20101 expression and histological type and differentiation of gastric carcinoma. Enhanced hGC\u20101 expression was more frequently seen in intestinal\u2010type adenocarcinoma, whereas loss of expression tended to occur in the diffuse type. hGC\u20101 was highly expressed in well or moderately differentiated cancers and was remarkably reduced or lost in poorly differentiated or undifferentiated tumours.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> These investigations have defined for the first time the expression pattern of hGC\u20101 in the normal human gastrointestinal tract and provide a novel and sensitive marker for the differentiation of gastric carcinoma.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2007.02763.x","type":"journal-article","created":{"date-parts":[[2007,6,30]],"date-time":"2007-06-30T13:13:57Z","timestamp":1183209237000},"page":"157-165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Expression of hGC\u20101 is correlated with differentiation of gastric carcinoma"],"prefix":"10.1111","volume":"51","author":[{"given":"W","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G P","family":"Rodgers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,6,30]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(01)00763-6"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.08.064"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.10.4655"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.molbev.a025975"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00590-1"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0016672300004584"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-3443"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2006.02.011"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/apm.1965.64.1.31"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.01.019"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-005-0320-0"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.5.623"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209279"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000070603"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000070087"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365520410003588"},{"key":"e_1_2_7_18_2","first-page":"291","article-title":"E\u2010cadherin and alpha\u2010catenin expression in human esophageal cancer","volume":"54","author":"Kadowaki T","year":"1994","journal-title":"Cancer Res."},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1159\/000086627"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004320000195"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.5.1858"},{"key":"e_1_2_7_22_2","first-page":"3845","article-title":"E\u2010cadherin gene mutations provide clues to diffuse type gastric carcinomas","volume":"54","author":"Becker KF","year":"1994","journal-title":"Cancer Res."},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2003.07.007"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199707)182:3<331::AID-PATH860>3.0.CO;2-D"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00190559"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.60.070191.001103"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.108.6.2435"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950101)75:1 <406::AID-CNCR2820751322>3.0.CO;2-W"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2559.2007.02763.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2559.2007.02763.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T08:31:37Z","timestamp":1697185897000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2559.2007.02763.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6,30]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["10.1111\/j.1365-2559.2007.02763.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2559.2007.02763.x","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6,30]]},"assertion":[{"value":"2007-06-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}