{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T18:52:00Z","timestamp":1782845520057,"version":"3.54.5"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,10,9]],"date-time":"2007-10-09T00:00:00Z","timestamp":1191888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:p><jats:bold>Aims:\u2002<\/jats:bold> To determine the immunophenotype of gastric and intestinal diffuse large B\u2010cell lymphomas and investigate the clinical significance of patterns of antigen expression.<\/jats:p><jats:p><jats:bold>Methods and results:\u2002<\/jats:bold> Immunohistochemistry was performed for detection of CD10, Bcl\u20106, Bcl\u20102, MUM1 and p53 in paraffin\u2010embedded tissue from 29 patients with primary diffuse large B\u2010cell lymphoma of the stomach and intestine. Statistical analysis was performed using \u03c7<jats:sup>2<\/jats:sup> and Fisher\u2019s exact tests. Survival data were analysed by the Kaplan\u2013Meier method and compared using a log rank test. Thirteen of the 29 cases were of germinal centre phenotype (CD10+ or CD10\u2013, Bcl\u20106+ and MUM1\u2013). Sixteen were of activated B\u2010cell phenotype (all CD10\u2013 and either Bcl\u20106\u2013, or Bcl\u20106+ and MUM1+). Sixteen cases showed Bcl\u20102 expression. There was a statistically significant difference (<jats:italic>P<\/jats:italic>\u2003&lt; 0.05) in immunophenotype of the neoplastic cells relating to tumour site. Of 15 gastric lymphomas, 11 were of activated B\u2010cell phenotype and 9\/14 intestinal tumours were of germinal centre phenotype. No significant survival difference was found between groups with regard to expression of any of the antigens investigated.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Primary gastric and intestinal large cell lymphomas appear to show different patterns of antigen expression. This suggests that these tumours arise by different mechanisms and\/or from different causes. Gastric diffuse large B\u2010cell lymphomas are usually of activated B\u2010cell phenotype that may reflect a relationship with low\u2010grade gastric lymphomas of marginal zone type. Intestinal diffuse large B\u2010cell lymphomas usually show a germinal centre phenotype, suggesting an origin from germinal centre B cells. In this study the tumour immunophenotype was not associated with any difference in survival.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2007.02855.x","type":"journal-article","created":{"date-parts":[[2007,10,9]],"date-time":"2007-10-09T09:02:00Z","timestamp":1191920520000},"page":"697-703","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Gastric and intestinal diffuse large B\u2010cell lymphomas are clinically and immunophenotypically different. An immunohistochemical and clinical study"],"prefix":"10.1111","volume":"51","author":[{"given":"J","family":"Connor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Ashton\u2010Key","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,10,9]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.8.2780"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2002.01538.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/35000501"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1545"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.4.1136"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012914"},{"key":"e_1_2_7_8_2","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1182\/blood.V90.1.244","article-title":"Prognostic significance of Bcl\u20102 protein expression and Bcl\u20102 gene rearrangement in diffuse aggressive non\u2010Hodgkin\u2019s lymphoma","volume":"90","author":"Gascoyne RD","year":"1997","journal-title":"Blood"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63150-1"},{"key":"e_1_2_7_10_2","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1182\/blood.V88.3.1046.1046","article-title":"Prognostic significance of BCL\u20102 expression and bcl\u20102 major breakpoint region rearrangement in diffuse large cell non\u2010Hodgkin\u2019s lymphoma: a British National Lymphoma Investigation Study","volume":"88","author":"M Hill ME","year":"1996","journal-title":"Blood"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.1.265.265"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11179"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2001.01196.x"},{"key":"e_1_2_7_14_2","doi-asserted-by":"crossref","first-page":"956","DOI":"10.5858\/2002-126-0956-CEIPIL","article-title":"CD10 expression in primary intestinal large B\u2010cell lymphomas","volume":"126","author":"Go J","year":"2002","journal-title":"Arch. Pathol. Lab. Med."},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200012000-00008"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-05-022517"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2003.01758.x"},{"key":"e_1_2_7_18_2","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1200\/JCO.1998.16.5.1931","article-title":"Clinical outcome in diffuse large B\u2010cell lymphoma is dependent on the relationship between different cell\u2010cycle regulator proteins","volume":"16","author":"Anchez E","year":"1998","journal-title":"J. Clin. Oncol."}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2559.2007.02855.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2559.2007.02855.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T08:54:02Z","timestamp":1697187242000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2559.2007.02855.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,9]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["10.1111\/j.1365-2559.2007.02855.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2559.2007.02855.x","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,9]]},"assertion":[{"value":"2007-10-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}