{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:23:03Z","timestamp":1761708183445},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,2,5]],"date-time":"2008-02-05T00:00:00Z","timestamp":1202169600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:p><jats:bold>Aims:\u2002<\/jats:bold> To present eight cases of a distinctive morphological subtype of lipomatous tumour of soft tissue.<\/jats:p><jats:p><jats:bold>Methods and results:\u2002<\/jats:bold> The clinicopathological, immunohistochemical and molecular pathological features of these tumours were analysed. The tumours were characterized by dense stromal sclerosis containing singly scattered pleomorphic atypical cells with lipoblastic features. The tumours occurred in four women and four men, aged 39\u201390\u2003years (mean\u2003=\u200363). They were located in the retroperitoneum, thigh, retropubic space, arm and spermatic cord. Four cases arose <jats:italic>de novo<\/jats:italic> and four cases presented as local recurrences of previously resected liposarcomas. MDM2 amplification and cyclophoshamide doxorubicin hydrochloride (adriamycin), vincristine and prednisolone (CHOP) translocation was studied in seven cases by fluorescence <jats:italic>in situ<\/jats:italic> hybridization. High\u2010level amplification of MDM2 at 12q13\u201015 was observed in 4\/7 cases. All cases were negative for the CHOP translocation; in one MDM2+\u2003case, the <jats:italic>CHOP<\/jats:italic> gene showed amplification but no translocation. Three patients died from their tumours from 1 to 6\u2003years after their last surgery with lung metastases.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> The tumours described appear to represent an unusual morphological variant of poorly differentiated liposarcoma associated with aggressive behaviour, and may represent a common end\u2010stage pathway for various types of liposarcoma.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2007.02936.x","type":"journal-article","created":{"date-parts":[[2008,2,5]],"date-time":"2008-02-05T11:08:57Z","timestamp":1202209737000},"page":"283-293","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Sclerosing poorly differentiated liposarcoma: clinicopathological, immunohistochemical and molecular analysis of a distinct morphological subtype of lipomatous tumour of soft tissue"],"prefix":"10.1111","volume":"52","author":[{"given":"S","family":"Suster","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Morrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,2,5]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"641","volume-title":"Enzinger and Weiss\u2019s soft tissue tumors","author":"Weiss SM","year":"2001"},{"key":"e_1_2_6_3_2","first-page":"187","volume-title":"Atlas of tumor pathology, fascicle 30, 3rd series","author":"Kempson RL","year":"2001"},{"key":"e_1_2_6_4_2","first-page":"34","volume-title":"World Health Organization classification of tumors","author":"Fletcher CDM","year":"2002"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.7127"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1997.5510791.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019606-200406000-00005"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213406.95440.7a"},{"key":"e_1_2_6_9_2","first-page":"623","article-title":"Correlation between clinicopathological features and karyotype in lipomatous tumors. 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