{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T23:44:43Z","timestamp":1769730283380,"version":"3.49.0"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,7,17]],"date-time":"2008-07-17T00:00:00Z","timestamp":1216252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:p><jats:bold>Aims:\u2002<\/jats:bold> The B\u2010cell\u2010specific transcription factor PAX\u20105 is physiologically expressed in normal B cells and silenced in plasma cells. The aim of this study was to determine whether PAX\u20105 expression is universal among B\u2010cell malignancies.<\/jats:p><jats:p><jats:bold>Methods and results:\u2002<\/jats:bold> A wide spectrum of B\u2010cell malignancies were subjected to immunohistochemical analysis for PAX\u20105 expression. The study was especially focused on cases lacking CD20, such as precursor B\u2010cell acute lymphoblastic leukaemia (preB\u2010ALL), CD20\u2212 B\u2010cell lymphomas, classical Hodgkin\u2019s lymphoma (CHL) and B\u2010cell lymphomas with significant plasmacytic differentiation. Strong PAX\u20105 expression was identified, without exception, in all cases of CD20+ B\u2010lymphoproliferative disorders. It was also invariably detected in 31\/31 cases of preB\u2010ALL, 14\/14 cases of CD20\u2212 diffuse large B\u2010cell lymphoma without plasmacytic differentiation and 26\/26 CD20\u2212 B\u2010cell lymphoma status post rituximab treatment. The vast majority of CHLs had unequivocal PAX\u20105 expression of varying intensity (80\/86). However, variants of B\u2010cell malignancies with characteristic plasmacytic differentiation exhibited no detectable PAX\u20105 expression (0\/17).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> PAX\u20105 is the most sensitive and reliable immunohistochemical marker for B\u2010cell malignancies. Lack of PAX\u20105 expression correlates with the presence of marked plasma cell differentiation.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2008.03091.x","type":"journal-article","created":{"date-parts":[[2008,7,17]],"date-time":"2008-07-17T09:04:10Z","timestamp":1216285450000},"page":"278-287","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["PAX\u20105 is invariably expressed in B\u2010cell lymphomas without plasma cell differentiation"],"prefix":"10.1111","volume":"53","author":[{"given":"H Y","family":"Dong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Browne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Gangi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,8,20]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"Pathology and genetics of tumors of hematopoietic and lymphoid tissues","author":"Jaffe ES","year":"2001"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002770100297"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880265"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1309\/3WG32YRAMQ7RB9D4"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.2.496"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63882-5"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1309\/UJUL60UPUP3YJE93"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.6.9.1589"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00153-4"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90079-5"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.4.1308.416k32_1308_1316"},{"key":"e_1_2_6_13_2","doi-asserted-by":"crossref","first-page":"3108","DOI":"10.1182\/blood.V94.9.3108","article-title":"Frequent expression of the B\u2010cell\u2010specific activator protein in Reed\u2013Sternberg cells of classical Hodgkin\u2019s disease provides further evidence for its B\u2010cell origin","volume":"94","author":"Foss HD","year":"1999","journal-title":"Blood"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1309\/YCH8DWUFFQBKGPVB"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200210000-00011"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2006.039917"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800778"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000173023.02724.1f"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.4.1406.004k26_1406_1412"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.2.645.bloodjournal882645"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.5.1483"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1309\/U98ADVKUC26R2RJA"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1545"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05690"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03843.x"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.03019.x"},{"key":"e_1_2_6_27_2","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1093\/ajcp\/112.6.844","article-title":"Lymphoid aggregates in bone marrow mimic residual lymphoma after rituximab therapy for non\u2010Hodgkin lymphoma","volume":"112","author":"Douglas VK","year":"1999","journal-title":"Am. 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