{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:05:31Z","timestamp":1793106331437,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,3,11]],"date-time":"2009-03-11T00:00:00Z","timestamp":1236729600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:p><jats:bold>Aims:\u2002<\/jats:bold> In T cells, protein kinase C (PKC) \u03b8 plays a major role in T\u2010cell receptor (TCR)\u2010mediated activation of a novel nuclear factor (NF)\u2010\u03baB pathway that involves phosphorylation of p65 at serine 536 (Pp65<jats:sup>Ser536<\/jats:sup>). Bcl\u201010 acts along the same pathway downstream of PKC \u03b8 to activate NF\u2010\u03baB. The aim was to investigate the relationship between the expression of PKC \u03b8, Bcl\u201010 and P\u2010p65<jats:sup>Ser536<\/jats:sup> proteins and their prognostic significance in peripheral T\u2010cell lymphomas (PTCLs).<\/jats:p><jats:p><jats:bold>Methods and results:\u2002<\/jats:bold> Paraffin\u2010embedded tissues from 30 patients with PTCLs treated with curative intention were evaluated retrospectively. Expression of PKC \u03b8, Bcl\u201010 and P\u2010p65<jats:sup>Ser536<\/jats:sup> proteins was assessed using immunohistochemistry. Expression of PKC \u03b8 was detected in 22 of 30 cases (73%), Bcl\u201010 in 20 of 30 (67%) and P\u2010p65<jats:sup>Ser536<\/jats:sup> in 21 of 30 (70%). Bcl\u201010+ tumours were associated with PKC \u03b8 (18 of 22) (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001) and Pp65Ser536 (19 of 21) expression (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001). Patients with Bcl\u201010+ or P\u2010p65<jats:sup>Ser536+<\/jats:sup> tumours fared better, with a 5\u2010year overall survival of 48 and 45%, respectively, versus 0% for negative tumours (<jats:italic>P<\/jats:italic>\u2003=\u20030.029 and <jats:italic>P<\/jats:italic>\u2003=\u20030.04, respectively).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Bcl\u201010 is expressed in PTCLs, correlates with PKC \u03b8 and Pp65<jats:sup>Ser536<\/jats:sup> expression and seems to be associated with better survival.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2009.03250.x","type":"journal-article","created":{"date-parts":[[2009,3,11]],"date-time":"2009-03-11T12:56:25Z","timestamp":1236776185000},"page":"478-485","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Bcl\u201010 protein highly correlates with the expression of phosphorylated p65 NF\u2010\u03baB in peripheral T\u2010cell lymphomas and is associated with clinical outcome"],"prefix":"10.1111","volume":"54","author":[{"given":"Javier","family":"Briones","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Moga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u00f1igo","family":"Espinosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Vergara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Villa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n","family":"Bordes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Delgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Prat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Sierra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,3,11]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-03-1306"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/hon.786"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(00)00083-2"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20031406"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209943"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2004.03.003"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(03)00177-7"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.10.010"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1368"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2004.11.009"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M504943200"},{"key":"e_1_2_7_13_2","first-page":"227","volume-title":"WHO classification of tumour. 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