{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:42:36Z","timestamp":1789382556004,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,11,26]],"date-time":"2009-11-26T00:00:00Z","timestamp":1259193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:p><jats:bold>Aims:\u2002<\/jats:bold> To investigate the clinicopathological characteristics of 20 primary gastric T\u2010cell lymphoma (GTCL) cases without human T\u2010lymphotropic virus type I infection in Japan, a non\u2010endemic area for coeliac disease.<\/jats:p><jats:p><jats:bold>Methods and results:\u2002<\/jats:bold> Fifteen cases had no history of persistent diarrhoea or severe hypoproteinaemia. Histologically, 13 cases (65%) consisted of large cell lymphoma and seven (35%) were of medium\u2010sized cells. Intraepithelial lymphoma cell invasion was found in three cases (15%). Two of 10 surgical cases (20%) showed intramucosal tumour cell spreading with enteropathy\u2010like features. <jats:italic>Helicobacter pylori CagA<\/jats:italic> gene was detected in three of 10 cases (30%). The lymphoma cells of all 20 cases were positive for CD3 and\/or TCR\u03b2F1 and negative for CD56. CD4\u2212 and CD8\u2212 lymphoma was found in 11 cases (55%), CD4+ lymphoma in seven (35%) and CD8+ lymphoma in two (10%). CD30+, CD5+ and CD25+ lymphomas were detected in nine (45%), 10 (50%) and 11 (55%) cases, respectively. Five\u2010year survival of the 16 available cases was 54%. Early clinical stage and medium\u2010sized cell lymphoma were significantly (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05) better prognostic factors.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Patients with GTCL exhibit distinct clinicopathological findings and prognoses from those with enteropathy\u2010associated T\u2010cell lymphomas. GTCL may be mainly derived from lamina propria and parafollicular T cells.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2009.03430.x","type":"journal-article","created":{"date-parts":[[2009,11,27]],"date-time":"2009-11-27T22:54:34Z","timestamp":1259362474000},"page":"641-653","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Clinicopathological characteristics of primary gastric T\u2010cell lymphoma"],"prefix":"10.1111","volume":"55","author":[{"given":"Kenichiro","family":"Kawamoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shotaro","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinori","family":"Iwashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiro","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumi","family":"Oshiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshifuku","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Nimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihiko","family":"Aoyagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Kuramochi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuji","family":"Matsuyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Kurihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Ohshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morishige","family":"Takeshita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,11,26]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2005.09.011"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70531-1"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.11.006"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1997.tb05084.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199902000-00003"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529609004870"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199804000-00010"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2004.01657.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1999.00566.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65736-7"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.03.036"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.02.027"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.114512"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.46.6377"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a058869"},{"key":"e_1_2_7_17_2","first-page":"1361","article-title":"Peripheral T\u2010cell lymphoma of the intestine","volume":"141","author":"Chott A","year":"1992","journal-title":"Am. 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