{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:44:36Z","timestamp":1791207876424,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,2,16]],"date-time":"2011-02-16T00:00:00Z","timestamp":1297814400000},"content-version":"vor","delay-in-days":46,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p>van de Winkel A, van Zoest K P M, van Dekken H, Moons L M G, Kuipers E J &amp; van der Laan L J W \u2028(2011) <jats:italic>Histopathology<\/jats:italic><jats:bold>58<\/jats:bold>, 246\u2013253\u2028<jats:bold>Differential expression of the nuclear receptors farnesoid X receptor (FXR) and pregnane X receptor (PXR) for grading dysplasia in patients with Barrett\u2019s oesophagus<\/jats:bold><\/jats:p><jats:p><jats:bold>Aims:\u2002<\/jats:bold> To investigate expression of nuclear receptors farnesoid X receptor (FXR) and pregnane X receptor (PXR) as a diagnostic tool to improve grading of dysplasia in Barrett\u2019s oesophagus patients.<\/jats:p><jats:p><jats:bold>Methods and results:\u2002<\/jats:bold> Immunostaining was analysed on a total of 192 biopsy samples of 22 Barrett\u2019s patients with no dysplasia (ND), 17 with low\u2010grade dysplasia (LGD), 20 high\u2010grade dysplasia (HGD) and 24 with adenocarcinoma (AC). Nuclear FXR expression was observed in 15 of 22 (68%) ND cases versus none of 19 HGD; 3 of 17 (18%); LGD; 5 of 60 (8%) patients with AC (<jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.001). FXR expression was highly specific for non\u2010dysplastic tissue. Nuclear PXR was expressed in 16 of 20 (80%) HGD cases versus two of 16 (13%) LGD cases (PPV 89%). Upon examining adjacent tissue taken from HGD and AC patients, PXR expression was high in samples of all tissue types.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Nuclear receptors are expressed differentially during neoplastic progression, with FXR positivity being useful to distinguish ND from dysplasia and AC. PXR nuclear expression is able to separate HGD from LGD and ND. The combination of FXR and PXR also appears to have diagnostic and possibly prognostic value, but future prospective studies are required to investigate their predictive power for neoplastic progression in Barret\u2019s oesophagus.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2011.03743.x","type":"journal-article","created":{"date-parts":[[2011,2,16]],"date-time":"2011-02-16T18:56:14Z","timestamp":1297882574000},"page":"246-253","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Differential expression of the nuclear receptors farnesoid X receptor (FXR) and pregnane X receptor (PXR) for grading dysplasia in patients with Barrett\u2019s oesophagus"],"prefix":"10.1111","volume":"58","author":[{"given":"Anouk","family":"van de Winkel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katinka P M","family":"van Zoest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman","family":"van Dekken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon M G","family":"Moons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernst J","family":"Kuipers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc J W","family":"van der Laan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,2,16]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03411-5"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(94)90057-4"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.01835.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.33427"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.00342.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.063685"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90420-H"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(89)80011-3"},{"key":"e_1_2_6_10_2","first-page":"586","article-title":"Barrett\u2019s esophagus, high\u2010grade dysplasia, and early adenocarcinoma: a pathological study","volume":"92","author":"Cameron AJ","year":"1997","journal-title":"Am. 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