{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:37:52Z","timestamp":1792175872620,"version":"4.4.0"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,2,16]],"date-time":"2011-02-16T00:00:00Z","timestamp":1297814400000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:p>Takeshita M, Nakamura S, Kikuma K, Nakayama Y, Nimura S, Yao T, Urabe S, Ogawara S, Yonemasu H, Matsushita Y, Karube K &amp; Iwashita A\u2028(2011) <jats:italic>Histopathology<\/jats:italic><jats:bold>58<\/jats:bold>, 395\u2013407\u2028<jats:bold>Pathological and immunohistological findings and genetic aberrations of intestinal enteropathy\u2010associated T cell lymphoma in Japan<\/jats:bold><\/jats:p><jats:p><jats:bold>Aims:\u2002<\/jats:bold> To elucidate the clinicopathological findings of primary intestinal enteropathy\u2010associated T cell lymphoma (EATL) in Japan, a non\u2010endemic area for coeliac disease.<\/jats:p><jats:p><jats:bold>Methods and results:\u2002<\/jats:bold> Of the 24 cases, four (17%) had large\u2010cell lymphoma (type I), and the remaining 20 (83%) had medium\u2010sized lymphoma (type II). Lymphoma cells of the three type I cases were CD56\u2010positive. Only one (4%) case showed typical CD56\u2010 and CD8\u2010negative and CD30\u2010positive type I EATL. In type II EATL, lymphoma cells of the 16 (80%) and 11 (55%) cases were positive for CD56 and CD8, respectively. Intramucosal tumour spreading and adjacent enteropathy\u2010like lesions were detected in 15 (71%) and 16 (76%) of 21 cases, with a severe increase of intraepithelial lymphocytes (IELs) in 12 (57%). IELs of enteropathy\u2010like lesions in five (24%) cases expressed T\u2010bet, with no cases of CD30\u2010positive IELs. Characteristic findings from comparative genomic hybridization of 15 cases indicated gains of 8q2 (47%), Xp (53%) and Xq (73%), but no gain of 9q3. Regarding, human leucocyte antigen (HLA) status, six cases examined did not express the DQB1*02 allele.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Japanese EATL exhibited different histology, cytogenetic findings and HLA status from those of typical type I EATL. The rare incidence of coeliac disease may influence the tumour cell characteristics of EATL and IELs.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2011.03768.x","type":"journal-article","created":{"date-parts":[[2011,2,16]],"date-time":"2011-02-16T18:01:55Z","timestamp":1297879315000},"page":"395-407","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Pathological and immunohistological findings and genetic aberrations of intestinal enteropathy\u2010associated T cell lymphoma in Japan"],"prefix":"10.1111","volume":"58","author":[{"given":"Morishige","family":"Takeshita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shotaro","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanta","family":"Kikuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshifuku","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Nimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Urabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Ogawara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotoshi","family":"Yonemasu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshifumi","family":"Matsushita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kennosuke","family":"Karube","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinori","family":"Iwashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,2,16]]},"reference":[{"key":"e_1_2_8_2_2","first-page":"289","volume-title":"WHO classification of tumors of haematopoietic and lymphoid tissues","author":"Isaacson PG","year":"2008"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.03.036"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64441-0"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1309\/NW2BK1DXB0EQG55H"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2005.12.011"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60254-3"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.22123"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2005.035345"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.6.3792"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2005.02237.x"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.3.372"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318159b478"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200602000-00012"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.6.804"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181a95c63"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1532\/IJH97.05131"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000115)88:2<286::AID-CNCR7>3.0.CO;2-Z"},{"key":"e_1_2_8_19_2","first-page":"1361","article-title":"Peripheral T\u2010cell lymphomas of the intestine","volume":"141","author":"Chott A","year":"1992","journal-title":"Am. J. Pathol."},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403202"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2008.02281.x"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(02)00925-1"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010201)91:3<525::AID-CNCR1030>3.0.CO;2-U"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-005-3173-6"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1080\/10428190310001653709"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyf107"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428190009053543"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02983532"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jjco.a023226"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.1996.tb03626.x"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2007.11.003"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.46.6377"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65736-7"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.LAB.0000090157.13040.58"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20245"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20386"},{"key":"e_1_2_8_37_2","first-page":"1694","article-title":"Expression of c\u2010myc oncoprotein in chronic T cell leukemias","volume":"9","author":"Maljaie SH","year":"1995","journal-title":"Leukemia"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365520802240222"},{"key":"e_1_2_8_39_2","first-page":"5817","article-title":"Interleukin\u20102 receptor \u03b3 chain mutation results in X\u2010linked severe combined immunodeficiency in humans","volume":"181","author":"Noguchi M","year":"2008","journal-title":"J. Immunol."},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200838199"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.2000.560606.x"},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0271-5317(02)00368-8"},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2007.01829.x"},{"key":"e_1_2_8_44_2","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B0820164"},{"key":"e_1_2_8_45_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20011956"},{"key":"e_1_2_8_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2008.03112.x"},{"key":"e_1_2_8_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00692-9"},{"key":"e_1_2_8_48_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199708000-00012"},{"key":"e_1_2_8_49_2","doi-asserted-by":"crossref","first-page":"e142","DOI":"10.5858\/2003-127-e142-NKTLOT","article-title":"Natural killer\u2010like T\u2010cell lymphoma of the small intestine with a distinct immunophenotype and lack of association with gluten\u2010sensitive enteropathy","volume":"127","author":"Yuan CM","year":"2003","journal-title":"Arch. Pathol. Lab. Med."}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2559.2011.03768.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2559.2011.03768.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T07:25:10Z","timestamp":1697354710000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2559.2011.03768.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["10.1111\/j.1365-2559.2011.03768.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2559.2011.03768.x","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2]]},"assertion":[{"value":"2011-02-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}