{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T13:29:41Z","timestamp":1785677381339,"version":"3.56.0"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,11,17]],"date-time":"2011-11-17T00:00:00Z","timestamp":1321488000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:p>Powell G, Roche H &amp; Roche W R \u2028(2011) <jats:italic>Histopathology<\/jats:italic><jats:bold>59<\/jats:bold>, 950\u2013956<\/jats:p><jats:p><jats:bold>Expression of calretinin by breast carcinoma and the potential for misdiagnosis of mesothelioma<\/jats:bold><\/jats:p><jats:p><jats:bold>Aims:\u2002<\/jats:bold> Calretinin and cytokeratin (CK)5\/6 are frequently used to differentiate between metastatic breast cancer and primary malignant mesothelioma in pleural biopsies, but both tumours may express these markers. This study was aimed at evaluating the frequency of calretinin expression in primary breast carcinomas, and assessing the characteristics of the calretinin\u2010positive tumours.<\/jats:p><jats:p><jats:bold>Methods and results:\u2002<\/jats:bold> Fifty\u2010three primary breast adenocarcinomas were analysed for immunohistochemical expression of calretinin. CK5\/6 and epidermal growth factor receptor (EGFR) immunostaining were performed on the calretinin\u2010positive subset. Tumours were classified as basal\u2010like if they met standard morphological and immunohistochemical criteria. Fifteen per cent (8\/53) of the breast tumours were positive for calretinin. Eighty\u2010eight per cent (7\/8) of the calretinin\u2010positive tumours were grade 3, as compared with 20% (9\/45) of the calretinin\u2010negative tumours (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). Only 13% (1\/8) of the calretinin\u2010positive tumours were also oestrogen receptor (ER)\u2010positive, as compared with 87% (39\/45) of the calretinin\u2010negative tumours (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). Eleven per cent (6\/53) of the tumours were classified as basal\u2010like. Of these, four were positive for calretinin and two were negative (<jats:italic>P<\/jats:italic>\u2003=\u20030.003).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Fifteen per cent of breast carcinomas stain with calretinin. These tumours are more likely to be high\u2010grade, ER\u2010negative, and display a basal\u2010like phenotype. These tumours may be misdiagnosed as malignant mesothelioma when they metastasize to the pleura.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2011.04031.x","type":"journal-article","created":{"date-parts":[[2011,11,17]],"date-time":"2011-11-17T18:45:12Z","timestamp":1321555512000},"page":"950-956","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Expression of calretinin by breast carcinoma and the potential for misdiagnosis of mesothelioma"],"prefix":"10.1111","volume":"59","author":[{"given":"George","family":"Powell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Roche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R","family":"Roche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,11,17]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:BREA.0000010706.24181.b6"},{"key":"e_1_2_6_3_2","unstructured":"Cancer Research UK.http:\/\/publications.cancerresearchuk.org\/WebRoot\/crukstoredb\/CRUK_PDFs\/breast\/cs_br_t2.1.xls. 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