{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:09:15Z","timestamp":1793725755132,"version":"4.6.1"},"reference-count":161,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,12,23]],"date-time":"2011-12-23T00:00:00Z","timestamp":1324598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p>\n                    Sfanos K S &amp; De Marzo A M \u2028(2012)\n                    <jats:italic>Histopathology<\/jats:italic>\n                    \u00a0\n                    <jats:bold>60<\/jats:bold>\n                    , 199\u2013215 \u2028\n                    <jats:bold>Prostate cancer and inflammation: the evidence<\/jats:bold>\n                  <\/jats:p>\n                  <jats:p>Chronic inflammation is now known to contribute to several forms of human cancer, with an estimated 20% of adult cancers attributable to chronic inflammatory conditions caused by infectious agents, chronic non\u2010infectious inflammatory diseases and\/or other environmental factors. Indeed, chronic inflammation is now regarded as an \u2018enabling characteristic\u2019 of human cancer. The aim of this review is to summarize the current literature on the evidence for a role for chronic inflammation in prostate cancer aetiology, with a specific focus on recent advances regarding the following: (i) potential stimuli for prostatic inflammation; (ii) prostate cancer immunobiology; (iii) inflammatory pathways and cytokines in prostate cancer risk and development; (iv) proliferative inflammatory atrophy (PIA) as a risk factor lesion to prostate cancer development; and (v) the role of nutritional or other anti\u2010inflammatory compounds in reducing prostate cancer risk.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2011.04033.x","type":"journal-article","created":{"date-parts":[[2011,12,24]],"date-time":"2011-12-24T07:25:17Z","timestamp":1324711517000},"page":"199-215","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":544,"title":["Prostate cancer and inflammation: the evidence"],"prefix":"10.1111","volume":"60","author":[{"given":"Karen S","family":"Sfanos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo M","family":"De Marzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,23]]},"reference":[{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20121"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2090"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.3.236"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2011.22"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12275-011-0391-z"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)65301-3"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1258\/rsmsmj.54.3.8"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-010-9825-5"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000277596"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.12.058"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.01.034"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.1999.00352.x"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2007.11.026"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/90.10.756"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-2608"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.2217\/fon.10.95"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000281331"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365590500199822"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(02)01637-0"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2006.04.075"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0913"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgh317"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008736"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.20680"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.06.008"},{"key":"e_1_2_10_27_2","article-title":"Acute bacterial inflammation of the mouse prostate","author":"Boehm BJ","year":"2011","journal-title":"Prostate"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605370"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.080747"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.21150"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.10.6515-6519.2001"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1127059"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02365-09"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2010.12.059"},{"key":"e_1_2_10_35_2","doi-asserted-by":"publisher","DOI":"10.1258\/0956462981922395"},{"key":"e_1_2_10_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.1996.tb00446.x"},{"key":"e_1_2_10_37_2","first-page":"87","article-title":"Subclinical prostatic inflammation attributable to Chlamydia trachomatis in a patient with prostate cancer","volume":"9","author":"Bielecki R","year":"2005","journal-title":"Med. 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