{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T13:29:40Z","timestamp":1785677380627,"version":"3.56.0"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,11,17]],"date-time":"2011-11-17T00:00:00Z","timestamp":1321488000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:p>Duhig E E, Kalpakos L, Yang I A &amp; Clarke B E \u2028(2011) <jats:italic>Histopathology<\/jats:italic><jats:bold>59<\/jats:bold>, 957\u2013964<\/jats:p><jats:p><jats:bold>Mesothelial markers in high\u2010grade breast carcinoma<\/jats:bold><\/jats:p><jats:p><jats:bold>Aims:\u2002<\/jats:bold> Advances in molecular profiling have subdivided breast carcinomas into distinct subtypes. Basal carcinomas are generally oestrogen receptor (ER)\u2212progesterone receptor (PR)\u2212\/human epidermal growth factor receptor 2 (HER2)\u2212, and cytokeratin (CK)5\/6+. This profile overlaps with that of mesothelial cells. This study of high\u2010grade breast carcinomas was undertaken to determine the expression of mesothelial markers.<\/jats:p><jats:p><jats:bold>Methods and results:\u2002<\/jats:bold> Immunohistochemistry was performed on 23 basal\u2010like breast carcinomas and 30 high\u2010grade breast carcinomas with variable ER, PR and HER2 expression. The incidence of staining of CK5\/6, CK14, calretinin, Wilms\u2019 tumour 1 (WT1), thrombomodulin and epithelial membrane antigen was assessed statistically. CK14 staining was more specifically associated with triple\u2010negative tumours than CK5\/6. Calretinin positivity was statistically associated with basal\u2010like carcinomas. WT1 and thrombomodulin expression was infrequent and limited to a small number of non\u2010basal carcinomas.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> There is an overlap between the immunophenotype of mesothelial cells and that of basal\u2010like carcinomas of breast. Positive calretinin and CK5\/6 are not specific, and may be seen in both mesothelial cells and basal\u2010like breast carcinomas. Negative ER and PR of basal carcinomas may also bias the observer against a breast origin. However, other negative mesothelial markers, such as WT1 and thrombomodulin, may help point to the correct diagnosis.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2011.04036.x","type":"journal-article","created":{"date-parts":[[2011,11,17]],"date-time":"2011-11-17T18:45:12Z","timestamp":1321555512000},"page":"957-964","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Mesothelial markers in high\u2010grade breast carcinoma"],"prefix":"10.1111","volume":"59","author":[{"given":"Edwina E","family":"Duhig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Kalpakos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian A","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda E","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,11,17]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1001389"},{"key":"e_1_2_8_3_2","doi-asserted-by":"crossref","first-page":"130","DOI":"10.5858\/134.1.130","article-title":"Basal\u2010like breast carcinoma. A phenotypically distinct entity","volume":"134","author":"Haupt B","year":"2010","journal-title":"Arch. Pathol. Lab. 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Cancer Res."},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800588"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800534"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e32832e05dd"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604340"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2559.2011.04036.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2559.2011.04036.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T14:49:10Z","timestamp":1698677350000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2559.2011.04036.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["10.1111\/j.1365-2559.2011.04036.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2559.2011.04036.x","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11]]},"assertion":[{"value":"2011-11-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}