{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:23:31Z","timestamp":1761823411443},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,12,23]],"date-time":"2011-12-23T00:00:00Z","timestamp":1324598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p>Lin C\u2010K, Tsai W\u2010C, Lin Y\u2010C &amp; Hueng D\u2010Y \u2028(2012) <jats:italic>Histopathology<\/jats:italic>\u00a0<jats:bold>60,<\/jats:bold> 320\u2013325 \u2028<jats:bold>Osteopontin predicts the behaviour of atypical meningioma<\/jats:bold><\/jats:p><jats:p><jats:bold>Aim:\u2002<\/jats:bold> Although the World Health Organization (WHO) histological criteria distinguishing benign from atypical and malignant meningioma are clear, discerning benign from atypical meningioma is still somewhat difficult, leading to interobserver diagnostic variability. Osteopontin (OPN) and cortactin play important roles in tumorigenesis, invasion and metastasis of several human cancers. The aim of this study was to evaluate the usefulness of OPN and cortactin immunohistochemistry for distinguishing between benign, atypical and malignant meningioma and predicting their recurrence.<\/jats:p><jats:p><jats:bold>Methods and results:\u2002<\/jats:bold> Seventy\u2010five specimens (48 benign, 17 atypical and 10 malignant meningiomas) were investigated immunohistochemically. The mean immunohistochemical scoreimmunohistochemical score\u2003\u00b1\u2003SE of the mean of both OPN and cortactin were significantly higher in grade II or grade III meningiomas than in grade I meningioma. Discriminant analysis of immunohistochemical OPN expression showed correct classification of 97.7% of WHO grade I meningiomas and 88.2% of WHO grade II meningiomas (95.4% accuracy). However, the same analysis of cortactin expression showed correct classification of 95.8% of WHO grade I meningiomas and only 23.5% of WHO grade II meningiomas (76.9% accuracy). A cut\u2010off for predicting grades I and II meningioma recurrence was determined for OPN (3.0) but not for cortactin. Finally, logistic regression identified both this cut\u2010off (<jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.05) and WHO grade (<jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.05) as independent risk factors for recurrence.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> OPN expression is a valuable marker for diagnosis of atypical meningioma and prediction of grades I and II meningioma recurrence.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2011.04085.x","type":"journal-article","created":{"date-parts":[[2011,12,24]],"date-time":"2011-12-24T20:46:35Z","timestamp":1324759595000},"page":"320-325","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Osteopontin predicts the behaviour of atypical meningioma"],"prefix":"10.1111","volume":"60","author":[{"given":"Chih\u2010Kung","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Chiuan","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Chun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dueng\u2010Yuan","family":"Hueng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,12,23]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:NEON.0000021823.05163.2c"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00307686"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1993.tb00752.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198603000-00001"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1981.55.6.0929"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19941215)74:12<3176::AID-CNCR2820741217>3.0.CO;2-N"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.2174\/156652406779010803"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4644(1998)72:30\/31 <92::AID-JCB13>3.0.CO;2-A"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-419X(01)00037-3"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.2174\/1566524013363339"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1014734930781"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4644(20000901)78:3<465::AID-JCB11>3.0.CO;2-C"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-008-9130-0"},{"key":"e_1_2_7_15_2","first-page":"1087","article-title":"Possible relation of osteopontin to development of psammoma bodies in human papillary thyroid cancer","volume":"122","author":"Tunio GM","year":"1998","journal-title":"Arch. 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