{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:29:13Z","timestamp":1766269753233},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,2,3]],"date-time":"2012-02-03T00:00:00Z","timestamp":1328227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p>Aigner F, Korol D, Schmitt A M &amp; Kurrer M O \u2028(2012) <jats:italic>Histopathology<\/jats:italic>\u00a0<jats:bold>60,<\/jats:bold> 774\u2013784<\/jats:p><jats:p><jats:bold>Extranodal diffuse large B cell lymphoma of cutaneous follicle centre lymphoma type: a study of 24 patients with non\u2010cutaneous primary limited stage extranodal diffuse large B cell lymphoma in support of a new concept<\/jats:bold><\/jats:p><jats:p><jats:bold>Aims:\u2002<\/jats:bold> Follicle centre cell lymphoma of small cell type showing either a follicular or diffuse growth pattern similar to cutaneous follicle centre lymphoma (cFCL) has been recognized in extranodal non\u2010cutaneous sites. Our aim was (i) to investigate whether diffuse large B cell lymphoma (DLBCL) of cFCL type could be identified in extranodal non\u2010cutaneous sites and (ii) whether clinical characteristics similar to primary cFCL could be recognized.<\/jats:p><jats:p><jats:bold>Methods and results:\u2002<\/jats:bold> Of 24 extranodal non\u2010cutaneous DLBCLs, nine (38%) had large centrocytoid morphology and 15 (62%) were either \u2018centrocytoid and centroblastic\u2019 or \u2018centroblastic and immunoblastic\u2019. Six centrocytoid cases were Irf\u20104 negative, Bcl\u20106 positive and at most weakly CD10\u2010 or Bcl\u20102\u2010positive by immunohistochemistry, consistent with DLBCL of cFCL type. All patients with cFCL type were stage IE and were significantly younger than other patients. Recurrences occurred in two patients and were exclusively extranodal.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Our results suggest that DLBCL of cFCL type can be identified in extranodal non\u2010cutaneous sites and shows clinical characteristics similar to genuine cFCL. We propose to expand the concept of cFCL to encompass large cell lymphomas in extranodal sites.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2011.04122.x","type":"journal-article","created":{"date-parts":[[2012,2,3]],"date-time":"2012-02-03T12:57:24Z","timestamp":1328273844000},"page":"774-784","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Extranodal diffuse large B cell lymphoma of cutaneous follicle centre lymphoma type: a study of 24 patients with non\u2010cutaneous primary limited stage extranodal diffuse large B cell lymphoma in support of a new concept"],"prefix":"10.1111","volume":"60","author":[{"given":"Fabian","family":"Aigner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitri","family":"Korol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja Maria","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael Odo","family":"Kurrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,2,3]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1182\/blood.V83.5.1165.1165","article-title":"Prognostic factors in aggressive non\u2010Hodgkin\u2019s lymphoma: who has \u2018high\u2010risk\u2019 disease?","volume":"83","author":"Shipp MA","year":"1994","journal-title":"Blood"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309303291402"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04749.x"},{"key":"e_1_2_7_5_2","first-page":"354","article-title":"EORTC classification for primary cutaneous lymphomas: a proposal from the cutaneous lymphoma study group of the European organization for research and treatment of cancer","volume":"90","author":"Willemze R","year":"1997","journal-title":"Blood"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3502"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(88)70169-3"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910501)67:9<2311::AID-CNCR2820670918>3.0.CO;2-0"},{"key":"e_1_2_7_9_2","first-page":"325","article-title":"Diffuse large cell lymphomas of follicular center cell origin presenting in the skin. 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