{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T14:46:55Z","timestamp":1793112415626,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,2,9]],"date-time":"2012-02-09T00:00:00Z","timestamp":1328745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p>Huang C, Sun Z, Sun Y, Chen X, Zhu X, Fan C, Liu B, Zhao Y &amp; Zhang W \u2028(2012) <jats:italic>Histopathology<\/jats:italic>\u00a0<jats:bold>60,<\/jats:bold> 793\u2013803<\/jats:p><jats:p><jats:bold>Association of increased ligand cyclophilin A and receptor CD147 with hypoxia, angiogenesis, metastasis and prognosis of tongue squamous cell carcinoma<\/jats:bold><\/jats:p><jats:p><jats:bold>Aims:\u2002<\/jats:bold> We evaluated the association of ligand cyclophilin A (CypA) and receptor CD147 with hypoxia, angiogenesis, lymph node metastasis and prognosis of patients with tongue squamous cell carcinoma (TSCC).<\/jats:p><jats:p><jats:bold>Methods and results:\u2002<\/jats:bold> We studied the expression of CypA, CD147, hypoxia\u2010inducible factor 1\u03b1 (HIF\u20101\u03b1), vascular endothelial growth factor A and C (VEGF\u2010A and VEGF\u2010C) protein by immunohistochemistry in 80 specimens of TSCC. CypA, CD147, HIF\u20101\u03b1, VEGF\u2010A and VEGF\u2010C were overexpressed in TSCCs, and were significantly higher than those in normal oral mucosa tissues (<jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.01). Increased ligand CypA and receptor CD147 correlated significantly with expression of HIF\u20101\u03b1, VEGF\u2010A and VEGF\u2010C. A significant relationship between VEGF\u2010A and VEGF\u2010C was also detected (<jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.01). Patients with overexpression of CypA, CD147, HIF\u20101\u03b1 and VEGF\u2010C had significantly worse overall survival (<jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.05) using Kaplan\u2013Meier analysis. Multivariate Cox regression analysis showed that HIF\u20101\u03b1, recurrence and distant metastasis were independent prognostic factors on overall survival in TSCC patients.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> The association of expression of ligand CypA and receptor CD147 with carcinogenesis, hypoxia, angiogenesis, metastasis and prognosis of TSCC suggests that ligand CypA and receptor CD147 may have prognostic value and could be regarded as potential therapeutic targets in TSCC.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2011.04130.x","type":"journal-article","created":{"date-parts":[[2012,2,9]],"date-time":"2012-02-09T22:40:41Z","timestamp":1328827241000},"page":"793-803","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Association of increased ligand cyclophilin A and receptor CD147 with hypoxia, angiogenesis, metastasis and prognosis of tongue squamous cell carcinoma"],"prefix":"10.1111","volume":"60","author":[{"given":"Congfa","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengchao","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2,9]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10266-010-0131-6"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81683-9"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20223"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20000601)88:11<2606::AID-CNCR25>3.0.CO;2-W"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-0241"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.10.2046"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(00)00573-3"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2010.02.006"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-1759"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.07.005"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.1.517"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.87.9.789"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63715-7"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0506317"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603425"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21862"},{"key":"e_1_2_8_18_2","volume-title":"International Union Against Cancer (UICC): TNM classification of malignant tumors","author":"Sobin LH","year":"2002"},{"key":"e_1_2_8_19_2","first-page":"168","volume-title":"World Health Organization classification of tumours. 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