{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:26:28Z","timestamp":1791285988747,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"6B","license":[{"start":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T00:00:00Z","timestamp":1330387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p>Sakellariou S, Al\u2010Hussaini H, Scalori A, Samyn M, Heaton N, Portmann B, Tobal K &amp; Quaglia A<\/jats:p><jats:p>(2012) <jats:italic>Histopathology<\/jats:italic>\u00a0<jats:bold>60,<\/jats:bold> E58\u2013E65<\/jats:p><jats:p><jats:bold>Hepatocellular adenoma in glycogen storage disorder type I: a clinicopathological and molecular study<\/jats:bold><\/jats:p><jats:p><jats:bold>Aims:\u2002<\/jats:bold> Glycogen storage disease type I is a metabolic disorder resulting from deficiency of the glucose\u20106\u2010phosphate complex. Long\u2010term complications include the development of hepatocellular adenoma (HCA). In this retrospective study, our aim was to reclassify according to geno\u2010phenotypic characteristics nodular lesions identified in hepatectomy specimens of such patients transplanted between 1998 and 2008 at our institution.<\/jats:p><jats:p><jats:bold>Methods and results:\u2002<\/jats:bold> Clinicopathological data of seven consecutive transplanted patients with glycogen storage disease type I were reviewed. Liver nodules were re\u2010examined histologically and by immunohistochemistry. Molecular analysis was performed additionally in a case with specific features. Four patients had multiple tumours. We concluded that 26 of 38 nodules available for study had features of inflammatory hepatocellular adenomas, seven comprised adenomas not otherwise specified and five were found to be focal nodular hyperplasia.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Further studies are needed to clarify the pathogenesis of hepatocellular adenomas in glycogen storage disease; in particular to determine whether they share abnormal metabolic pathways with inflammatory adenomas in the general population. Testing for acute phase proteins may be a helpful tool in the early detection of HCA in such patients. Finally, there is a need to further define their risk of malignant transformation, in relation to age and possible cofactors.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2011.04153.x","type":"journal-article","created":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T14:50:55Z","timestamp":1330440655000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Hepatocellular adenoma in glycogen storage disorder type I: a clinicopathological and molecular study"],"prefix":"10.1111","volume":"60","author":[{"given":"Stratigoula","family":"Sakellariou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussa","family":"Al\u2010Hussaini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Scalori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Samyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel","family":"Heaton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Portmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"Tobal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Quaglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2,28]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02680007"},{"issue":"1","key":"e_1_2_7_3_2","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1007\/BF02679990","article-title":"Glycogen storage disease type I: diagnosis, management, clinical course and outcome. 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