{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:54:56Z","timestamp":1787014496679,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,2,20]],"date-time":"2012-02-20T00:00:00Z","timestamp":1329696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>\n                    Rossi G, Gasser B, Sartori G, Migaldi M, Costantini M, Mengoli M C, Piccioli S, Cavazza A &amp; Rivasi F \u2028(2012)\n                    <jats:italic>Histopathology<\/jats:italic>\n                    \u00a0\n                    <jats:bold>60,<\/jats:bold>\n                    1133\u20131143\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      MUC5AC, cytokeratin 20 and HER2 expression and\n                      <jats:italic>K\u2010RAS<\/jats:italic>\n                      mutations within mucinogenic growth in congenital pulmonary airway malformations\n                    <\/jats:bold>\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Aims:\u2002<\/jats:bold>\n                    To analyse the expression of several mucins (MUC1, MUC2, MUC3, MUC5AC and MUC6), epidermal growth factor receptor (EGFR), v\u2010erb\u2010b2 erythroblastic leukaemia viral oncogene homologue 2 (HER2), thyroid transcription factor\u20101 (TTF\u20101), caudal type homeobox 2 (CDX2) and cytokeratin 20 (CK20), and the presence of mutations of\n                    <jats:italic>EGFR<\/jats:italic>\n                    ,\n                    <jats:italic>KRAS<\/jats:italic>\n                    and\n                    <jats:italic>HER2<\/jats:italic>\n                    in congenital pulmonary airway malformations (CPAM).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods and results:\u2002<\/jats:bold>\n                    Forty\u2010one cases of CPAM and six pulmonary sequestrations were included. TTF\u20101 expression was observed in all cases but was not seen in mucinogenic growths in CPAM. CDX2 expression was completely negative. MUC1 expression was noted in 12 (29%) CPAM and in 33% sequestrations. MUC5AC was noted in only five cases (26%) by immunohistochemistry and was found in the mucinogenic proliferations of type 1 CPAM. No immunolabelling was noted for the other mucins. EGFR was expressed variably in almost all cases, while HER2 and CK20 was seen exclusively in the mucinogenic proliferations. All mucinous growths were characterized by\n                    <jats:italic>KRAS<\/jats:italic>\n                    mutations. No\n                    <jats:italic>EGFR<\/jats:italic>\n                    and\n                    <jats:italic>HER2<\/jats:italic>\n                    gene alterations were identified.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:\u2002<\/jats:bold>\n                    <jats:italic>KRAS<\/jats:italic>\n                    mutations and MUC5AC, CK20 and HER2 expression was seen in all mucinogenic proliferations, supporting the neoplastic nature of these cytologically bland growths. These findings emphasize the importance of complete surgical resection of such lesions.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-2559.2011.04170.x","type":"journal-article","created":{"date-parts":[[2012,2,20]],"date-time":"2012-02-20T14:59:36Z","timestamp":1329749976000},"page":"1133-1143","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["MUC5AC, cytokeratin 20 and HER2 expression and\n                    <i>K\u2010RAS<\/i>\n                    mutations within mucinogenic growth in congenital pulmonary airway malformations"],"prefix":"10.1111","volume":"60","author":[{"given":"Giulio","family":"Rossi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Gasser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliana","family":"Sartori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Migaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Costantini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cecilia","family":"Mengoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Piccioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Cavazza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Rivasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2,20]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"221","article-title":"Congenital adenomatoid malformation of one lobe of a lung with general anasarca","volume":"48","author":"Ch\u2019in KY","year":"1949","journal-title":"Arch. 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