{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:58:42Z","timestamp":1791824322682,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"6B","license":[{"start":{"date-parts":[[2012,3,6]],"date-time":"2012-03-06T00:00:00Z","timestamp":1330992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p>Stewart C J R, Leung Y C &amp; Whitehouse A<\/jats:p><jats:p>(2012) <jats:italic>Histopathology<\/jats:italic>\u00a0<jats:bold>60,<\/jats:bold> E106\u2013E114<\/jats:p><jats:p>Fallopian tube metastases of non\u2010gynaecological origin: a series of 20 cases emphasizing patterns of involvement including intra\u2010epithelial spread<\/jats:p><jats:p><jats:bold>Aims:\u2002<\/jats:bold> To determine the frequency and distribution of Fallopian tube involvement in patients with ovarian metastases of non\u2010gynaecological origin.<\/jats:p><jats:p><jats:bold>Methods and results:\u2002<\/jats:bold> All Fallopian tube tissue was processed for histological examination in a consecutive series of 31 patients with ovarian metastases of non\u2010gynaecological origin. The most common primary sites were appendix (n\u2003=\u200310) colon (n\u2003=\u20037), stomach (n\u2003=\u20036) and breast (n\u2003=\u20034). Twenty cases (65%) showed at least one type of tubal spread. Mural involvement was most common (14 cases) but serosal, intra\u2010vascular, intra\u2010epithelial and intra\u2010lumenal spread were also identified in 12, 9, 8 and 11 cases respectively. Intra\u2010epithelial involvement was restricted to the fimbrial epithelium and mimicked tubal carcinoma <jats:italic>in situ<\/jats:italic> (CIS) architecturally. Pagetoid invasion was noted in two of the cases.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> The Fallopian tubes are commonly involved in patients who have neoplasms metastatic to the ovaries. Metastases may show a CIS\u2010like pattern of intra\u2010epithelial spread and therefore small serous CIS\u2010type lesions may not represent proof of tubal tumour origin in patients who have high\u2010stage pelvic serous carcinomas. The frequency of intra\u2010lumenal tumour cells supports transtubal spread as a likely mechanism for mucosal involvement by metastatic tumours involving the lower genital tract.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2012.04194.x","type":"journal-article","created":{"date-parts":[[2012,3,6]],"date-time":"2012-03-06T16:53:29Z","timestamp":1331052809000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Fallopian tube metastases of non\u2010gynaecological origin: a series of 20 cases emphasizing patterns of involvement including intra\u2010epithelial spread"],"prefix":"10.1111","volume":"60","author":[{"given":"Colin J R","family":"Stewart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yee C","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Whitehouse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840501)53:9<1978::AID-CNCR2820530929>3.0.CO;2-1"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0b013e3180504abf"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pgp.0000168514.06429.c3"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/IGC.0b013e3181b33cce"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-8258(03)00075-1"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2006.00302.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-0489-8_11"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000331294"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/00313020903042604"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2004.12.002"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-199810000-00011"},{"key":"e_1_2_6_13_2","first-page":"585","volume-title":"Haines and Taylor obstetrical and gynaecological patholog","author":"Honore LH","year":"2003"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e3181c1158e"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2009.03367.x"},{"key":"e_1_2_6_16_2","first-page":"683","article-title":"Primary carcinoma of the fallopian tubes","volume":"51","author":"Holland WW","year":"1930","journal-title":"Surg. Gynecol. Obstet."},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(194909)2:5<803::AID-CNCR2820020510>3.0.CO;2-K"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(69)90579-1"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181cf3d79"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-010-0599-0"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pgp.0000179614.47838.82"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181758831"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e3181ebc781"},{"key":"e_1_2_6_24_2","first-page":"398","article-title":"Abnormal cervical Pap smear leading to the diagnosis of gastrointestinal cancer without cervico\u2010vaginal metastases","volume":"14","author":"Selvaggi LE","year":"1993","journal-title":"Eur. J. Gynaecol. Oncol."},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1159\/000328569"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2010.12.002"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.3.768"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199709000-00007"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1080\/02841860310018053"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181d6b8fd"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318211b3d2"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213335.40358.47"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181ef7b16"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2010.11.020"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199412000-00003"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1988.tb02028.x"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2008.03202.x"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2007.00939.x"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2003.10.005"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2006.21.4.752"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2011.02670.x"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e3181f45f28"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2559.2012.04194.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2559.2012.04194.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T06:32:44Z","timestamp":1698647564000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2559.2012.04194.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,6]]},"references-count":41,"journal-issue":{"issue":"6B","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.1111\/j.1365-2559.2012.04194.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2559.2012.04194.x","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,6]]},"assertion":[{"value":"2012-03-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}