{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T23:50:56Z","timestamp":1789861856889,"version":"4.0.1"},"reference-count":54,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,6,13]],"date-time":"2012-06-13T00:00:00Z","timestamp":1339545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>Kato S, Takahashi E, Asano N, Tanaka T, Megahed N, Kinoshita T &amp; Nakamura S \u2028(2012) <jats:italic>Histopathology<\/jats:italic>\u00a0<jats:bold>61,<\/jats:bold> 186\u2013199<\/jats:p><jats:p><jats:bold>Nodal cytotoxic molecule (CM)\u2010positive Epstein\u2013Barr virus (EBV)\u2010associated peripheral T cell lymphoma (PTCL): a clinicopathological study of 26 cases<\/jats:bold><\/jats:p><jats:p><jats:bold>Aims:\u2002<\/jats:bold> The clinicopathological distinctiveness of nodal cytotoxic molecule (CM)\u2010positive Epstein\u2013Barr virus (EBV)\u2010associated peripheral T cell lymphoma (PTCL) remains to be clarified. We investigated 26 patients with this lymphoma compared to nodal CM<jats:sup>+<\/jats:sup> EBV<jats:sup>\u2212<\/jats:sup> PTCL (<jats:italic>n\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>39) and extranasal natural killer\/T cell lymphoma of nasal type (ENKTL, <jats:italic>n\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>44).<\/jats:p><jats:p><jats:bold>Methods and results:\u2002<\/jats:bold> Nodal CM<jats:sup>+<\/jats:sup> EBV<jats:sup>+<\/jats:sup> PTCL patients were more likely to have B symptoms (<jats:italic>P\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.019) and hepatic involvement (<jats:italic>P\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.026) than nodal CM<jats:sup>+<\/jats:sup> EBV<jats:sup>\u2212<\/jats:sup> PTCL patients. The former also had more Stage III\/IV disease (<jats:italic>P\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.025) but much less cutaneous involvement (<jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.001) than ENKTL patients at diagnosis. This nodal EBV<jats:sup>+<\/jats:sup> lymphoma possessed a distinctive immunophenotype of high CD8<jats:sup>+<\/jats:sup>, CD56<jats:sup>\u2212<\/jats:sup> pattern with an aggressive clinical course (median, 6.6\u2003months). Thrombocytopenia was present in 11 (50%) patients and found to be the strongest prognostic indicator (<jats:italic>P\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.001) in this nodal EBV<jats:sup>+<\/jats:sup> group. For all nodal CM<jats:sup>+<\/jats:sup> PTCL cases CD5 negativity, but not EBV positivity, was the significant adverse prognostic factor (<jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.002) in a multivariate analysis, independent of prognostic index for PTCL (PIT) or International Prognostic Index (IPI) scores.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Nodal CM<jats:sup>+<\/jats:sup> EBV<jats:sup>+<\/jats:sup> PTCL constitutes a unique group of lymphomas distinct from ENKTL. The data provide support for our assertion that nodal CM<jats:sup>+<\/jats:sup> PTCL should be distinguished in the 2008 WHO category of PTCL, not otherwise specified.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2012.04199.x","type":"journal-article","created":{"date-parts":[[2012,6,13]],"date-time":"2012-06-13T10:19:48Z","timestamp":1339582788000},"page":"186-199","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Nodal cytotoxic molecule (CM)\u2010positive Epstein\u2013Barr virus (EBV)\u2010associated peripheral T cell lymphoma (PTCL): a clinicopathological study of 26 cases"],"prefix":"10.1111","volume":"61","author":[{"given":"Seiichi","family":"Kato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiko","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Asano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirmeen","family":"Megahed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Kinoshita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeo","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,13]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.4558"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.5.1361.1361"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1827.2003.01479.x"},{"key":"e_1_2_7_5_2","volume-title":"World Health Organization classification of tumours of haematopoietic and lymphoid tissues","author":"Swerdlow SH","year":"2008"},{"issue":"2","key":"e_1_2_7_6_2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/annonc\/8.suppl_2.S17","article-title":"Classification of T\u2010cell and NK\u2010cell neoplasms based on the REAL classification","volume":"8","author":"Jaffe ES","year":"1997","journal-title":"Ann. 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