{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T12:57:07Z","timestamp":1774357027226,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,3,6]],"date-time":"2012-03-06T00:00:00Z","timestamp":1330992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p>Huss S, Wardelmann E, Goltz D, Binot E, Hartmann W, Merkelbach\u2010Bruse S, B\u00fcttner R &amp; Schildhaus H\u2010U (2012) <jats:italic>Histopathology<\/jats:italic>\u00a0<jats:bold>61,<\/jats:bold> 59\u201368<\/jats:p><jats:p><jats:bold>Activating <jats:italic>PDGFRA<\/jats:italic> mutations in inflammatory fibroid polyps occur in exons 12, 14 and 18 and are associated with tumour localization<\/jats:bold><\/jats:p><jats:p><jats:bold>Aims:\u2002<\/jats:bold> Inflammatory fibroid polyps (IFP) are mesenchymal tumours of the gastrointestinal tract. This study was performed to broaden the base of evidence of the pathogenic role of <jats:italic>PDGFR<\/jats:italic> mutations in IFP with particular regard to clinicopathological data and mutational patterns among IFP subtypes.<\/jats:p><jats:p><jats:bold>Methods and results:\u2002<\/jats:bold> Molecular analysis of 38 tumours revealed activating mutations in three different exons of <jats:italic>PDGFRA<\/jats:italic> in 25 IFP. For the first time we report two cases with <jats:italic>PDGFRA<\/jats:italic>\u2010exon 14 mutations (p.N659K; p.[N659K(+)T665A]). The results of our study and cases reported earlier indicate clearly that there is a localization\u2010specific pattern: exon 12 mutations predominate in the small intestine, while exon 18 mutations occur frequently in the stomach (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). Codons 567\u2013571 of <jats:italic>PDGFRA<\/jats:italic> represent an IFP specific mutational hot spot and are affected most frequently by deletions. Furthermore, in our series IFP of the stomach share common features. In contrast to intestinal IFP, gastric tumours occur at higher age, show heavy inflammation and tend to be smaller. IFP located in the small intestine are frequently associated with intussusception.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> We conclude that there is a \u2018small bowel\u2019 and a \u2018gastric\u2019 phenotype of IFPs which are associated with exon 12 and exon 18 <jats:italic>PDGFRA<\/jats:italic> mutations, respectively.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2012.04203.x","type":"journal-article","created":{"date-parts":[[2012,3,6]],"date-time":"2012-03-06T16:51:59Z","timestamp":1331052719000},"page":"59-68","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":91,"title":["Activating <i>PDGFRA<\/i> mutations in inflammatory fibroid polyps occur in exons 12, 14 and 18 and are associated with tumour localization"],"prefix":"10.1111","volume":"61","author":[{"given":"Sebastian","family":"Huss","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Wardelmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane","family":"Goltz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elke","family":"Binot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Merkelbach\u2010Bruse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard","family":"B\u00fcttner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans\u2010Ulrich","family":"Schildhaus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,3,6]]},"reference":[{"key":"e_1_2_8_2_2","first-page":"397","article-title":"Gastric submucosal granuloma with eosinophilic infiltration","volume":"25","author":"Vanek J","year":"1949","journal-title":"Am. J. Pathol."},{"key":"e_1_2_8_3_2","first-page":"335","article-title":"Inflammatory fibroid polyps of the stomach","volume":"96","author":"Helwig EB","year":"1953","journal-title":"Surg. Gynecol. Obstet."},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(81)80106-9"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199311000-00009"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1998.00433.x"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.33.7.1004"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.2393"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa025217"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-1578(10)60510-7"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700122"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.14.068"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2003.09.003"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2009.62"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-008-0715-5"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.05.140"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1079666"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.16.3457"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700360"},{"key":"e_1_2_8_20_2","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1097\/PAI.0b013e3181db500a","article-title":"A case of imatinib\u2010naive ileal fibrous stromal tumour with unusual morphology and double PDGFRA mutation","volume":"18","author":"Daum O","year":"2010","journal-title":"Appl. Immunohistochem. Mol. Morphol."},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64472-0"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65461-2"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-010-0914-8"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2559.2012.04203.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2559.2012.04203.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T10:10:54Z","timestamp":1697364654000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2559.2012.04203.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,6]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1111\/j.1365-2559.2012.04203.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2559.2012.04203.x","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,6]]},"assertion":[{"value":"2012-03-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}