{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T23:31:28Z","timestamp":1791070288193,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,3,22]],"date-time":"2012-03-22T00:00:00Z","timestamp":1332374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p>Wang C\u2010C, Liau J\u2010Y, Lu Y\u2010S, Chen J\u2010W, Yao Y\u2010T &amp; Lien H\u2010C \u2028(2012) <jats:italic>Histopathology<\/jats:italic>\u00a0<jats:bold>61,<\/jats:bold> 78\u201387<\/jats:p><jats:p><jats:bold>Differential expression of moesin in breast cancers and its implication in epithelial\u2013mesenchymal transition<\/jats:bold><\/jats:p><jats:p><jats:bold>Aims:\u2002<\/jats:bold> Moesin belongs to the ERM (ezrin, radixin and moesin) family. Recent <jats:italic>in\u2010vitro<\/jats:italic> studies have shown the possible involvement of moesin in epithelial\u2013mesenchymal transition (EMT), but correlating <jats:italic>in\u2010vivo<\/jats:italic> evidence is lacking.<\/jats:p><jats:p><jats:bold>Methods and results:\u2002<\/jats:bold> To study the biological significance of moesin, we used immunohistochemistry to investigate the <jats:italic>in\u2010situ<\/jats:italic> expression profiles of moesin in 322 breast carcinomas of different subtypes, including 23 cases of metaplastic carcinoma (MCB) which is pathogenetically considered to involve EMT. Moesin was highly expressed in 95.7% of cases of MCB, and in 16% of cases of invasive ductal carcinoma (IDC), but was negative in all other subtypes of breast carcinomas. In IDCs, moesin expression correlated positively with a high histological grade (<jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.001), basal\u2010like phenotype (<jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.001) and poor overall survival (<jats:italic>P <\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.0263). Transfection of MCF7 cells with Snail, one of the key regulators of EMT, showed up\u2010regulation of moesin at the transcriptional level. Finally, mRNA level of moesin correlated positively with Snail and EMT\u2010related genes in a microarray data set using primary breast cancer samples.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> These results offer biological evidence of moesin as an EMT marker, support the association between moesin, Snail and EMT and suggest a role for moesin in breast cancer prognostication.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2012.04204.x","type":"journal-article","created":{"date-parts":[[2012,3,23]],"date-time":"2012-03-23T10:10:12Z","timestamp":1332497412000},"page":"78-87","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Differential expression of moesin in breast cancers and its implication in epithelial\u2013mesenchymal transition"],"prefix":"10.1111","volume":"61","author":[{"given":"Chung\u2010Chieh","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jau\u2010Yu","family":"Liau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen\u2010Shen","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Tung","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huang\u2010Chun","family":"Lien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,22]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.49.34507"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2866"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-1323-03"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/mc.20193"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-7-268"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780174"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22923"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20654"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.95.1.333"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208927"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc822"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/00313020701329914"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.11.007"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2009.01419.x"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.056523"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.03218"},{"key":"e_1_2_8_18_2","first-page":"13","volume-title":"World Health Organization Classification of Tumor. 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