{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T07:41:49Z","timestamp":1778139709817,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,5,29]],"date-time":"2012-05-29T00:00:00Z","timestamp":1338249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p>Hsiao S\u2010C, Cortada I R, Colomo L, Ye H, Liu H, Kuo S\u2010Y, Lin S\u2010H, Chang S\u2010T, Kuo T U, Campo E &amp; Chuang S\u2010S \u2028(2012) <jats:italic>Histopathology<\/jats:italic>\u00a0<jats:bold>61,<\/jats:bold> 685\u2013693<\/jats:p><jats:p><jats:bold>SOX11 is useful in differentiating cyclin D1\u2010positive diffuse large B\u2010cell lymphoma from mantle cell lymphoma<\/jats:bold><\/jats:p><jats:p><jats:bold>Aims:\u2002<\/jats:bold> To characterize the frequency and clinicopathological features of cyclin D1\u2010positive diffuse large B\u2010cell lymphoma (DLBCL) and the usefulness of SOX11 in the differential diagnosis from mantle cell lymphoma (MCL).<\/jats:p><jats:p><jats:bold>Methods and results:\u2002<\/jats:bold> We retrospectively stained 206 consecutive DLBCLs for cyclin D1, and identified three (1.5%) positive cases, comprising two in the elderly with necrosis, and a third with a starry\u2010sky pattern. All three cases shared the same non\u2010germinal centre B\u2010cell (non\u2010GCB) phenotype [CD5\u2212\/CD10\u2212\/bcl\u20106+\/MUM1+\/SOX11\u2212], Epstein\u2013Barr virus (EBV) negativity, and absence of <jats:italic>CCND1<\/jats:italic> aberrations by fluorescence <jats:italic>in\u2010situ<\/jats:italic> hybridization. The third case showed both <jats:italic>BCL6<\/jats:italic> and <jats:italic>MYC<\/jats:italic> rearrangements: a double\u2010hit lymphoma. In the same period there were 22 MCLs, all expressing cyclin D1, with 89% cases expressing SOX11, a frequency that is statistically different from cyclin D1\u2010positive DLBCL. Notably, we identified a pleomorphic MCL initially misdiagnosed as DLBCL. A separate cohort of 98 DLBCL cases was negative for SOX11, with only one case expressing cyclin D1 with a GCB phenotype (CD10+\/bcl\u20106+\/MUM1\u2212). The two patients with tumour necrosis rapidly died of disease. The other two were in complete remission after immunochemotherapy.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Cyclin D1\u2010positive DLBCLs are rare, and they are negative for SOX11 or <jats:italic>CCND1<\/jats:italic> aberration. SOX11 is useful in differentiating cyclin D1\u2010positive DLBCL from MCL.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2012.04260.x","type":"journal-article","created":{"date-parts":[[2012,5,29]],"date-time":"2012-05-29T17:15:17Z","timestamp":1338311717000},"page":"685-693","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["SOX11 is useful in differentiating cyclin D1\u2010positive diffuse large B\u2010cell lymphoma from mantle cell lymphoma"],"prefix":"10.1111","volume":"61","author":[{"given":"Shih\u2010Chuan","family":"Hsiao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inmaculada Ribera","family":"Cortada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Colomo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongtao","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Szu\u2010Yin","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu\u2010Hui","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng\u2010Tsung","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ted U","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elias","family":"Campo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih\u2010Sung","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,5,29]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.8.2726.2726"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a010568"},{"key":"e_1_2_8_4_2","doi-asserted-by":"crossref","first-page":"92","DOI":"10.5858\/2005-129-92-CLSLLW","article-title":"Chronic lymphocytic leukemia\/small lymphocytic lymphoma with trisomy 12 and focal cyclin d1 expression: a potential diagnostic pitfall","volume":"129","author":"O\u2019Malley DP","year":"2005","journal-title":"Arch. 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