{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:59:03Z","timestamp":1791075543672,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,6,20]],"date-time":"2012-06-20T00:00:00Z","timestamp":1340150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:p>Matsukuma S, Takeo H, Kono T, Nagata Y &amp; Sato K \u2028(2012) <jats:italic>Histopathology<\/jats:italic>\u00a0<jats:bold>61,<\/jats:bold> 857\u2013862<\/jats:p><jats:p><jats:bold>Aberrant cytokeratin 7 expression of centrilobular hepatocytes: a clinicopathological study<\/jats:bold><\/jats:p><jats:p><jats:bold>Aims:\u2002<\/jats:bold> This study has attempted to elucidate the clinicopathological features of aberrant cytokeratin 7 (CK7) expression by centrilobular hepatocytes.<\/jats:p><jats:p><jats:bold>Methods and results:\u2002<\/jats:bold> A total of 113 liver biopsy specimens from patients with common non\u2010neoplastic liver diseases, including hepatitis B or C, non\u2010alcoholic steatohepatitis, alcoholic liver disease and other diseases were examined. In 56 specimens (49.6%), CK7\u2010positive centrilobular hepatocytes (CK7\u2003+\u2003CHs) were identified and sometimes showed binuclear features. CK7\u2003+\u2003CHs were associated with patients\u2019 older age (<jats:italic>P<\/jats:italic>\u2003=\u20030.004), higher serum levels of aspartate aminotransferase (<jats:italic>P<\/jats:italic>\u2003=\u20030.016) and \u03b3\u2010glutamyltransferase (<jats:italic>P<\/jats:italic>\u2003=\u20030.006), centrilobular fibrosis (<jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.001), prominent thickening of hepatocytic plates (<jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.001) and higher scores of total and periportal CK7\u2010positive hepatocytes (both <jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.001), but were not correlated with gender, steatosis, serum levels of total bilirubin or alanine aminotransferase. In 55 cases of hepatitis B and hepatitis C only, CK7\u2003+\u2003CHs were related to a higher stage of fibrosis (<jats:italic>P<\/jats:italic>\u2003=\u20030.006).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> CK7\u2003+\u2003CHs occur relatively frequently in non\u2010neoplastic liver disease, associated with centrilobular scarring and the presence of CK7\u2010positive periportal hepatocytes, and appear to be a non\u2010specific phenomenon with respect aetiology of underlying disease. CK7\u2003+\u2003CHs may represent age\u2010dependent activation of hepatic progenitor cells or a regenerative phenomenon of hepatocytes themselves, both of which might contribute to liver regeneration.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2012.04278.x","type":"journal-article","created":{"date-parts":[[2012,3,23]],"date-time":"2012-03-23T06:44:11Z","timestamp":1332485051000},"page":"857-862","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Aberrant cytokeratin 7 expression of centrilobular hepatocytes: a clinicopathological study"],"prefix":"10.1111","volume":"61","author":[{"given":"Susumu","family":"Matsukuma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Takeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takako","family":"Kono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuiko","family":"Nagata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimiya","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,20]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"1101","article-title":"Expression of bile duct\u2010type cytokeratin in noncancerous hepatocytes in patients with hepatitis B virus\u2010related hepatocellular carcinoma","volume":"50","author":"Uenishi T","year":"2003","journal-title":"Hepato-Gastroenterol."},{"key":"e_1_2_7_3_2","volume-title":"Diagnostic immunohistochemistry","author":"Dabbs DJ","year":"2006"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.08.017"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-010-0957-x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hepres.2006.07.014"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.175"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPNRXCAP92KNOJ"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.05.002"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22333"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22218"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182254283"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(91)90084-O"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50193"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20650"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.05.012"},{"key":"e_1_2_7_17_2","volume-title":"Sleisenger & Fordtran\u2019s gastrointestinal and liver disease","author":"Feldman M","year":"2006"},{"key":"e_1_2_7_18_2","first-page":"1425","article-title":"Nodular regenerative hyperplasia of the liver. 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